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Globosides

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Definition: Glycosphingolipids containing N-acetylglucosamine (paragloboside) or N-acetylgalactosamine (globoside). Globoside is the P antigen on erythrocytes and paragloboside is an intermediate in the biosynthesis of erythrocyte blood group ABH and P 1 glycosphingolipid antigens. The accumulation of globoside in tissue, due to a defect in hexosaminidases A and B, is the cause of Sandhoff disease.  /biosyn /physiol permitted    Other names Lacto-N-tetraosylceramide; Lacto-N-neotetraosylceramide; Cytolipins; Lacto N tetraosylceramide; Lacto N neotetraosylceramide; Lactoneotetraosylceramide
 
SubstanceCAS Registry & nameCategoriesSourceDrugs*
6-O-sulfosialylparagloboside  0   *Globosides. Carbohydr Res 2008 Jul 21;343(10-11):1849-57
thioisoglobotrihexosylceramide  0   *Globosides *Trihexosylceramides. Org Lett 2006 Nov 23;8(24):5493-6
NOR2 glycolipid  0   *Globosides. Glycobiology 2007 Mar;17(3):304-12
isoglobotrihexosylceramide  0   *Globosides *Trihexosylceramides. Org Lett 2006 Mar 2;8(5):911-4
globotrihexosylceramide  0   *Globosides *Trihexosylceramides. Org Lett 2006 Mar 2;8(5):911-4
galactopyranosyl-1-4-paragloboside  0   *Globosides. J Biol Chem 2003 Nov 7;278(45):44429-38
galactopyranosyl-1-4-N-acetylgalactosaminyl-1-3-galactopyranosyl-1-4-galactopyranosyl-1-4-glucopyranosylceramide  0   *Globosides. Transfusion 2002 Jun;42(6):806-7
lysogloboside-4-azidosalicylamide  0   *Globosides. Biochim Biophys Acta 1995 Aug 3;1257(3):265-73
Shiga-like toxin receptor  0   *Glycolipids *Receptors, Cell Surface Globosides. Int Immunol 1990;2(1):1
3-sulfoglucuronyl-lactosaminyl-paragloboside  129429-42-1   *Globosides. J Neurochem 1990;55(2):594
O-acetyldisialosyl paragloboside  128543-21-5   *Globosides. J Neurochem 1990;54(5):1598
3-sulfoglucuronyl-lacto-N-norhexaosylceramide  106907-69-1   *Globosides. J Neurochem 1990;54(5):1589
3-sulfoglucuronyl-lacto-N-neotetraosylceramide  104625-47-0   *Globosides. J Neurochem 1990;54(5):1589
N-glycosylsialoparagloboside  72626-26-7   *Globosides. Arch Biochem Biophys 1989;270(1):391
N-acetylglucosyl--2-mannosyl--3-mannosyl--4-glucosyl--1-ceramide  98824-96-5   *Globosides. Biochim Biophys Acta 1988;962(2):159
sulfate-3-glucuronyl paragloboside  0   *Globosides. Chem Phys Lipids 1986;42(1-3):235
sialosyllactosaminylparagloboside  71833-58-4   *Globosides. J Neuroimmunol 1987;14(2):189
cytolipin P  72412-89-6   *Globosides. Bilt Hematol Transfuz 1983;11(2-3):33
sialosylgloboside  86168-20-9 Globoside I, O-(N-acetyl-alpha-neuraminosyl)-(1-3D)  *Globosides Antigens, Neoplasm. Biochem Biophys Res Commun 1983;112(3):935
fucosylgloboside  86168-21-0 Globoside I, O-6-deoxy-alpha-L-galactopyranosyl-(1-D)  *Globosides Antigens, Neoplasm. Biochem Biophys Res Commun 1983;112(3):935
isoglobotriaosylceramide  84593-23-7 Ganglioside G(A3), O-alpha-D-galactopyranosyl-(1-3B)  *Globosides. Biochim Biophys Acta 1983;750(1):214
paragloboside  56573-54-7   *Globosides. Eur J Biochem 1982;125(2):323; J Biochem (Tokyo) 1982;92(4):1123
globotetraose  75660-79-6   *Globosides. Infection 1982;10(5):327
globotetraosylceramide  11034-93-8 Globoside I  *Globosides. Lipid Res 21(1):53;1980
alpha-fucosylneolactotetraosylceramide  0   *Globosides. J Lipid Res 21(1):53;1980
disialosyl paragloboside  83713-05-7 Ceramide, 1-O- (O-(N-acetyl-alpha-neuraminosyl)-(2-8)-O-(N-acetyl-alpha-neuraminosyl)-(2-3)-O-beta-D-galactopyranosyl-(1-4)-O-2-(acetylamino)-2-deoxy-beta-D-glucopyranosyl-(1-3)-O-beta-D-galactopyranosyl-(1-4))-.  *Globosides. Biochim Biophys Acta 531(3):266;1978
sialosylparagloboside  71833-57-3 Paragloboside, O-(N-acetyl-alpha-neuraminosyl)-(2-3D)  *Globosides. Vox Sang 32(5):257;1977
Forssman glycolipid  60267-39-2 Forssman globoside  *Globosides Forssman Antigen. Cancer Res 35(7):1723;1975; J Biochem (Tokyo) 75(1):197;1974; Jap J Exptl Med 45(4):293;1975
cytolipin R  12244-28-9   *Globosides Antigens, Neoplasm. J Biochem (Tokyo) 76(5):1067;1974; J Biochem (Tokyo) 81:1661;1977

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Sources: NLM Medical Subject Headings, NIH UMLS, Drugs@FDA, FDA AERS original data copyright United States Government. No endorsement implied. Last modified 6/6/2012
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