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Glutamate-Ammonia Ligase

More information in Books or onNLM PubMed
Definition: An enzyme that catalyzes the conversion of ATP, L-glutamate, and NH3 to ADP, orthophosphate, and L-glutamine. It also acts more slowly on 4-methylene-L-glutamate. (From Enzyme Nomenclature, 1992) EC 6.3.1.2.      Other names Glutamine Synthetase; Synthetase, Glutamine; Ligase, Glutamate-Ammonia; Glutamate Ammonia Ligase; Glutamate Ammonia Ligase (ADP)
 
SubstanceCAS Registry & nameCategoriesSourceDrugs*
Glutamine deficiency, congenital  0   *Amino Acid Metabolism, Inborn Errors Glutamate-Ammonia Ligase/deficiency.
2,6-diamino-5-hydroxyhexanoic acid  0   *Hexanoic Acids Glutamate-Ammonia Ligase/antagonists & inhibitors. Bioorg Med Chem 2008 May 15;16(10):5501-13
(3-(diethoxyphosphoryl)phenylamino)acetic acid  0   *Organophosphorus Compounds Glutamate-Ammonia Ligase/antagonists & inhibitors. Bioorg Med Chem 2008 May 15;16(10):5501-13
lengsin protein, mouse  0   *Eye Proteins Glutamate-Ammonia Ligase. J Biol Chem 2008 Mar 7;283(10):6607-15
LGSN protein, human  EC 6.3.1.2   *Glutamate-Ammonia Ligase. Int J Mol Med 2005 Dec;16(6):1163-7
GLN2 protein, Arabidopsis  EC 6.3.1.2   *Glutamate-Ammonia Ligase *Arabidopsis Proteins. Plant Cell 2004 Aug;16(8):2048-58
PIID regulatory protein, Bacteria  57657-57-5 Uridylyltransferase, glutamine synthetase adenylytransferase-regulating protein  *Bacterial Proteins *PII Nitrogen Regulatory Proteins Genes, Regulator Glutamate-Ammonia Ligase/metabolism Protein Kinases. Anal Biochem 90(2):752;1978; J Bacteriol 1989;171(101):5638; Proc Natl Acad Sci USA 1980;77(5):2636
glutamine synthetase 2  EC 6.3.1.-   *Glutamate-Ammonia Ligase. J Gen Microbiol 1993 Aug;139( Pt 8):1773-83
glutamine synthetase I  EC 6.3.1.-   *Glutamate-Ammonia Ligase Escherichia coli Proteins. J Bacteriol 1993 May;175(10):2961-9
4-N-hydroxy-2,4-diaminobutyric acid  111821-59-1   *Aminobutyric Acids Glutamate-Ammonia Ligase/antagonists & inhibitors. J Med Chem 1988;31(2):480
tabtoxinine beta-lactam  65709-93-5   *Azetidines Bacterial Toxins Glutamate-Ammonia Ligase/antagonists & inhibitors Pseudomonas. J Biol Chem 1987;262(4):1608
phosphinothricin  51276-47-2   *Aminobutyric Acids Glutamate-Ammonia Ligase/antagonists & inhibitors.
Pharma Action Enzyme Inhibitors ; Herbicides 		Helv Chim Acta 55(1):224;1972

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Sources: NLM Medical Subject Headings, NIH UMLS, Drugs@FDA, FDA AERS original data copyright United States Government. No endorsement implied. Last modified 6/6/2012
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