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Hemicholinium 3

More information in Books or onNLM PubMed
Definition: A potent inhibitor of the high affinity uptake system for CHOLINE. It has less effect on the low affinity uptake system. Since choline is one of the components of ACETYLCHOLINE, treatment with hemicholinium can deplete acetylcholine from cholinergic terminals. Hemicholinium 3 is commonly used as a research tool in animal and in vitro experiments.     
Pharmacological Action Cholinergic Agents; Neurotransmitter Uptake Inhibitors 		Other names Hemicholinium
 
SubstanceCAS Registry & nameCategoriesSourceDrugs*
alpha,alpha-bis(dimethylammoniumacetaldehyde diethylacetal)-4,4-diacetylbiphenyl  13717-24-3   Hemicholinium 3/*analogs & derivatives. Naunyn Schmiedebergs Arch Pharmacol 1986;332(3):230
hemicholinium 15-bromo mustard  83291-95-6 2-Morpholinol, 4-(2-bromoethyl)-2-phenyl  Hemicholinium 3/*analogs & derivatives. J Med Chem 1983;26(1):104
hemicholinium 3-bromo mustard  79868-97-6 2-Morpholinol, 2,2'-(1,1'-biphenyl)-4,4'-diylbis(4-(2-bromoethyl)-, dihydrochloride)  Hemicholinium 3/*analogs & derivatives. Neuroscience 1981;6(9):1765
4-terphenylhemicholinium 3  29605-98-9   Hemicholinium 3/*analogs & derivatives. Br J Pharmacol 44(2):324P;1972
acetyl-seco-hemicholinium-3  40374-51-4   Hemicholinium 3/*analogs & derivatives. Nature 243(5405):285;1973

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Sources: NLM Medical Subject Headings, NIH UMLS, Drugs@FDA, FDA AERS original data copyright United States Government. No endorsement implied. Last modified 6/6/2012
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