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Hemoglobinuria, Paroxysmal

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Definition: A condition characterized by the recurrence of HEMOGLOBINURIA caused by intravascular HEMOLYSIS. In cases occurring upon cold exposure (paroxysmal cold hemoglobinuria), usually after infections, there is a circulating antibody which is also a cold hemolysin. In cases occurring during or after sleep (paroxysmal nocturnal hemoglobinuria), the clonal hematopoietic stem cells exhibit a global deficiency of cell membrane proteins.      Other names Paroxysmal Nocturnal Hemoglobinuria; Paroxysmal Cold Hemoglobinuria; Syndrome, Marchiafava-Micheli; Nocturnal Paroxysmal Hemoglobinuria; Marchiafava Micheli Syndrome; Hemoglobinuria, Paroxysmal Nocturnal; Hemoglobinuria, Paroxysmal Cold; Hemoglobinuria, Nocturnal Paroxysmal; Hemoglobinuria, Cold Paroxysmal; Cold Paroxysmal Hemoglobinuria; Paroxysmal Hemoglobinuria, Nocturnal; Paroxysmal Hemoglobinuria, Cold; Paroxysmal Hemoglobinuria; Marchiafava-Micheli Syndrome
 
SubstanceCAS Registry & nameCategoriesSource
Glycosylphosphatidylinositol deficiency  0   *Hemoglobinuria, Paroxysmal Glycosylphosphatidylinositols/deficiency.
Bone Marrow failure syndromes  0   *Hemoglobinuria, Paroxysmal.

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Sources: NLM Medical Subject Headings, NIH UMLS, Drugs@FDA, FDA AERS original data copyright United States Government. No endorsement implied. Last modified 6/6/2012
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