Definition: A congenital or acquired condition of insufficient production of ALDOSTERONE by the ADRENAL CORTEX leading to diminished aldosterone-mediated synthesis of Na(+)-K(+)-EXCHANGING ATPASE in renal tubular cells. Clinical symptoms include HYPERKALEMIA, sodium-wasting, HYPOTENSION, and sometimes metabolic ACIDOSIS.
do not confuse with HYPERALDOSTERONISM or PSEUDOHYPOALDOSTERONISM
Other names Type IV Renal Tubular Acidosis; Renal Tubular Acidosis, Type IV; Hypoaldosteronism, Hyporeninemic; Acidosis, Renal Tubular Type IV; Hyporeninemic Hypoaldosteronism
