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Lactose Synthase

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Definition: An enzyme of the transferase class that catalyzes the transfer of galactose from UDPgalactose to glucose, forming lactose. The enzyme is a complex of the enzyme N-ACETYLLACTOSAMINE SYNTHASE and alpha-lactalbumin; the latter protein is present in lactating mammary gland cells where it alters the usual specificity of the former to make lactose synthesis the preferred reaction. (Dorland, 28th ed) EC 2.4.1.22.      Other names Lactose Synthetase; Synthetase, Lactose; Synthase, Lactose; N Acetylgucosamide 1 4 beta Galactosyl Transferase; N-Acetylgucosamide 1-4 beta Galactosyl Transferase
 
SubstanceCAS Registry & nameCategoriesSourceDrugs*
4-deoxy-D-xylo-hexose  7286-46-6 D-xylo-hexose, 4-deoxy  *Deoxy Sugars Lactose Synthase/antagonists & inhibitors. Carbohydr Res 1980;81(2):239
4-azido-4-deoxyglucose  20379-59-3   Deoxyglucose/*analogs & derivatives Lactose Synthase/antagonists & inhibitors. Carbohydr Res 1980;81(2):239

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Sources: NLM Medical Subject Headings, NIH UMLS, Drugs@FDA, FDA AERS original data copyright United States Government. No endorsement implied. Last modified 6/6/2012

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