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Leucomycins

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Definition: An antibiotic complex produced by Streptomyces kitasatoensis. The complex consists of a mixture of at least eight biologically active components, A1 and A3 to A9. Leucomycins have both antibacterial and antimycoplasmal activities.  do not confuse with LEUCOMYCIN see KITASAMYCIN   
Pharmacological Action Anti-Bacterial Agents
Examples Kitasamycin; Spiramycin
 
SubstanceCAS Registry & nameCategoriesSourceDrugs*
23-O-mycinosyl-20-dihydro-rosamicin  0   *Leucomycins. J Antibiot (Tokyo). 2010 Jun;63(6):325-8
3,4''-didespropionylmidecamycin A3  0   *Leucomycins. Appl Microbiol Biotechnol 2004 Nov;66(1):53-62
9a-chloromethyl-1,2,9,9a-tetrahydrocyclopropa(c)benz(e)indol-4-one  0   *Leucomycins Cross-Linking Reagents. Bioorg Med Chem 1993 Jul;1(1):27-38
2-(PDE-I-dimer)-1,2,9,9a-tetrahydrocyclopropa(c)benz(e)indol-4-one  149251-66-1   *Leucomycins. J Med Chem 1993 Jul 9;36(14):1956-63
leucomycin A6  18361-48-3   *Leucomycins. Yao Hsueh Hsueh Pao 1991;26(2):156
CPI-CDPI(2)  114251-19-3   *Leucomycins. Biochemistry 1990;29(42):9994
antibiotic 6108C  130812-06-5 Cirramycin A1, 20-((2-amino-2-carboxyethyl)thio)-20-deoxo-20-hydroxy  *Leucomycins. J Antibiot (Tokyo) 1990;43(8):938
antibiotic 6108B  130812-05-4 Cirramycin A1, 19-carboxy-19-de(oxomethyl)  *Leucomycins. J ANtibiot (Tokyo) 1990;43(8):938
antibiotic 6108A1  130812-04-3 Cirramycin A1, 20-(acetylhydrazone)  *Leucomycins. J Antibiot (Tokyo) 1990;43(8):938
antibiotic 6108D  130812-07-6 Cirramycin A1, 6-de(2-oxoethyl)-6-(4-oxo-2-pentenyl)  *Leucomycins. J Antibiot (Tokyo) 1990;43(8):938
rosaramicin  35834-26-5   *Leucomycins. Antibiot Khimioter 1988;33(2):102
carbomycin  4564-87-8   *Leucomycins.
cirramycin A1  25339-90-6   *Leucomycins Macrolides. J Antibiot (Tokyo) 1989;42(2):242
cirramycin F2  120851-46-9   *Leucomycins Macrolides. J Antibiot (Tokyo) 1989;42(2):242
cirramycin F1  74918-31-3   *Leucomycins Macrolides. J Antibiot (Tokyo) 1989;42(2):242
macrocin  11049-15-3   *Leucomycins. J Chromatogr 1984;288(1):157
mycaminosyltylonolide  61257-02-1   *Leucomycins. J Antibiot (Tokyo) 1981;34(10):1377
de-epoxy rosamicin  56689-42-0 Cirramycin A1, 12,13-deepoxy-12,13-didehydro-4'-deoxy-, (12E)  *Leucomycins. J Antibiot (Tokyo) 1981;34(6):719
midecamycin  35457-80-8   *Leucomycins Macrolides.
Pharma Action Anti-Bacterial Agents
antibiotics M-4365  76773-74-5 Antibiotic M 4365  *Leucomycins Macrolides. J Antibiot (Tokyo) 30(6):443;1977; J Antibiot (Tokyo) 31(5):433;1978
turimycin  39405-35-1   *Leucomycins Macrolides. Arch Exp Veterinaermed 32(5):653;1978; Arch Exp Veterinaermed 33(1):111;1979; Arch Microbiol 121(1):92;1979; Arch Toxicol (Suppl 1):235;1978; Exp Pathol 1979;17(7-8):513; J Antibiot (Tokyo) 29(12):1314;1976; J Antibiot (Tokyo) 30(6):488;1977; Pharmazie 1979;34(5-6):338-342; Pharmazie 30(6):366;1975; Pharmazie 31(3):190;1976; Pharmazie 32(8-9):472;1977; Pharmazie 33(9):611;1978; Z Allg Mikrobiol 15(4):249;1975
maridomycin III  35775-82-7   *Leucomycins Macrolides. J Antibiot (Tokyo) 28(6):434;1975; J Antibiot (Tokyo) 29(8):824;1976
propionylmaridomycin  39386-19-1   *Leucomycins Macrolides. Antimicrob Agents Chemother 6(6):685;1974; J Chromatogr 1979;169:337; J Jpn Assoc Infect Dis 48(9):357;1974; J Jpn Assoc Infect Dis 49(8):330;1975
leuconolide-A(3)-5,18-hemiacetal  52442-90-7   *Leucomycins. J Antibiot (Tokyo) 27(2):147;1974
9-dehydro-18-dihydroleuconolide-A(3)  52442-94-1   *Leucomycins. J Antibiot (Tokyo) 27(2):147;1974

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Sources: NLM Medical Subject Headings, NIH UMLS, Drugs@FDA, FDA AERS original data copyright United States Government. No endorsement implied. Last modified 6/6/2012
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