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Lipoprotein Lipase

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Definition: An enzyme of the hydrolase class that catalyzes the reaction of triacylglycerol and water to yield diacylglycerol and a fatty acid anion. The enzyme hydrolyzes triacylglycerols in chylomicrons, very-low-density lipoproteins, low-density lipoproteins, and diacylglycerols. It occurs on capillary endothelial surfaces, especially in mammary, muscle, and adipose tissue. Genetic deficiency of the enzyme causes familial hyperlipoproteinemia Type I. (Dorland, 27th ed) EC 3.1.1.34.  /defic: consider also HYPERLIPOPROTEINEMIA TYPE I   
See Also Hyperlipoproteinemia Type I 		Other names Lipemia-Clearing Factor; Heparin-Clearing Factor; Post Heparin Lipase; Lipoprotein Lipase, Postheparin; Lipemia Clearing Factor; Lipase, Postheparin Lipoprotein; Lipase, Postheparin; Lipase, Post-Heparin; Lipase, Lipoprotein; Lipase, Diglyceride; Lipase, Diacylglycerol; Heparin Clearing Factor; Factor, Lipemia-Clearing; Factor, Heparin-Clearing; Postheparin Lipoprotein Lipase; Postheparin Lipase; Post-Heparin Lipase; Diglyceride Lipase; Diacylglycerol Lipase
 
SubstanceCAS Registry & nameCategoriesSourceDrugs*
LPL protein, human  EC 3.1.1.34   *Lipoprotein Lipase.
Lipase deficiency combined  0   *Lipid Metabolism, Inborn Errors Lipoprotein Lipase/deficiency.
LPL binding proteins, human  0   *Receptors, Cell Surface Lipoprotein Lipase.
diacylglycerol lipase beta, human  EC 3.1.1.34   *Lipoprotein Lipase. J Cell Biol. 2003 Nov 10;163(3):463-8
diacylglycerol lipase alpha, human  EC 3.1.1.34   *Lipoprotein Lipase. J Cell Biol. 2003 Nov 10;163(3):463-8
lipolytic enzyme L2, Aspergillus oryzae  EC 3.1.1.-   *Fungal Proteins *Lipoprotein Lipase *Monoacylglycerol Lipases. FEMS Microbiol Lett 1996 Sep 15;143(1):63-7
phenyl-n-butylborinic acid  100757-73-1   *Boron Compounds Sterol Esterase/antagonists & inhibitors Lipoprotein Lipase/antagonists & inhibitors. Biochem Biophys Res Commun 1986;134(1):386
1,6-bis(cyclohexyloximinocarbonyl)hexane  83654-05-1 Cyclohexanone, O,O'-(1,6-hexanediylbis(iminocarbonyl))dioxime  *Cyclohexanones Lipoprotein Lipase/antagonists & inhibitors.
Pharma Action Protease Inhibitors 		J Biol Chem 1982;257(23):14006

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Sources: NLM Medical Subject Headings, NIH UMLS, Drugs@FDA, FDA AERS original data copyright United States Government. No endorsement implied. Last modified 6/6/2012
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