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Procollagen-Lysine, 2-Oxoglutarate 5-Dioxygenase

More information in Books or onNLM PubMed
Definition: A mixed-function oxygenase that catalyzes the hydroxylation of peptidyllysine, usually in protocollagen, to peptidylhydroxylysine. The enzyme utilizes molecular oxygen with concomitant oxidative decarboxylation of the cosubstrate 2-oxoglutarate to succinate. EC 1.14.11.4.  DF: note short X ref    Other names Protocollagen Lysyl Hydroxylase; Lysine Hydroxylase; Lysine 2-Oxoglutarate Dioxygenase; Procollagen Lysine, 2 Oxoglutarate 5 Dioxygenase; Lysine 2 Oxoglutarate Dioxygenase; Hydroxylase, Protocollagen Lysyl; Hydroxylase, Lysyl; Hydroxylase, Lysine; Hydroxylase, Collagen Lysyl; 5-Dioxygenase Procollagen-Lysine, 2-Oxoglutarate; Dioxygenase, Lysine 2-Oxoglutarate; 2-Oxoglutarate Dioxygenase, Lysine; 2-Oxoglutarate 5-Dioxygenase Procollagen-Lysine; Lysyl Hydroxylase; Collagen Lysyl Hydroxylase
 
SubstanceCAS Registry & nameCategoriesSourceDrugs*
PLOD1 protein, human  EC 1.14.11.4   *Procollagen-Lysine, 2-Oxoglutarate 5-Dioxygenase. Hum Genet. 2012 Apr;131(4):591-9
lysyl hydroxylase 2, zebrafish  EC 1.14.11.4   *Procollagen-Lysine, 2-Oxoglutarate 5-Dioxygenase *Zebrafish Proteins. Matrix Biol 2007 Jan;26(1):12-9
lysyl hydroxylase 1, zebrafish  EC 1.14.11.4   *Procollagen-Lysine, 2-Oxoglutarate 5-Dioxygenase *Zebrafish Proteins. Matrix Biol 2007 Jan;26(1):12-9
LH3 protein, zebrafish  0   *Procollagen-Lysine, 2-Oxoglutarate 5-Dioxygenase *Glycosyltransferases *Zebrafish Proteins. Neuron 2006 Jun 1;50(5):683-95
lysyl hydroxylase 3, mouse  EC 1.14.11.-   *Procollagen-Lysine, 2-Oxoglutarate 5-Dioxygenase. J Cell Physiol 2006 Jun;207(3):644-53
lysyl hydroxylase 1, human  EC 1.14.11.4   *Procollagen-Lysine, 2-Oxoglutarate 5-Dioxygenase. Am J Med Genet 2004 Dec 1;131A(2):155-62
PLOD2 protein, human  EC 1.14.11.4   *Procollagen-Lysine, 2-Oxoglutarate 5-Dioxygenase. J Biol Chem 2003 Oct 17;278(42):40967-72
lysyl hydroxylase 3, human  EC 1.14.11.-   *Procollagen-Lysine, 2-Oxoglutarate 5-Dioxygenase. Marrix Biol 2002 Nov;21(7):559-66

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Sources: NLM Medical Subject Headings, NIH UMLS, Drugs@FDA, FDA AERS original data copyright United States Government. No endorsement implied. Last modified 6/6/2012
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