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Muscimol

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Definition: A neurotoxic isoxazole isolated from species of AMANITA. It is obtained by decarboxylation of IBOTENIC ACID. Muscimol is a potent agonist of GABA-A RECEPTORS and is used mainly as an experimental tool in animal and tissue studies.     
Pharmacological Action GABA-A Receptor Agonists
See Also Receptors, GABA-A 		Other names Pantherine; Agarin
 
SubstanceCAS Registry & nameCategoriesSourceDrugs*
N,N-dimethylmuscimol  58728-65-7   Muscimol/*analogs & derivatives. J Neurosci Res 1992 Jan;31(1):166-74
N-methylmuscimol  58893-38-2   Muscimol/*analogs & derivatives. J Neurosci Res 1992 Jan;31(1):166-74
N,N-dimethylthiomuscimol  83913-02-4   Muscimol/*analogs & derivatives. J Neurosci Res 1992 Jan;31(1):166-74
isomuscimol  26384-22-5   *Muscimol Isomerism. J Theor Biol 1987;127(4):479
thiomuscimol  62020-54-6 5-(aminomethyl)- 3(2H)-isothiazolone  Muscimol/*analogs & derivatives. J Neurochem 32(6):1717;1979
dihydromuscimol  72241-46-4 3-Isoxazolidinone, 5-(aminomethyl)  *Oxazolidinones Muscimol/*analogs & derivatives. J Neurochem 32(6):1717;1979

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Sources: NLM Medical Subject Headings, NIH UMLS, Drugs@FDA, FDA AERS original data copyright United States Government. No endorsement implied. Last modified 6/6/2012
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