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Muscle Spasticity

More information in Books or onNLM PubMed
Definition: A form of muscle hypertonia associated with upper MOTOR NEURON DISEASE. Resistance to passive stretch of a spastic muscle results in minimal initial resistance (a "free interval") followed by an incremental increase in muscle tone. Tone increases in proportion to the velocity of stretch. Spasticity is usually accompanied by HYPERREFLEXIA and variable degrees of MUSCLE WEAKNESS. (From Adams et al., Principles of Neurology, 6th ed, p54)  skeletal muscle only; note category: not physiological; spastic paralysis: coord NIM with PARALYSIS (IM); spasticity in cerebral palsy: coord NIM with CEREBRAL PALSY only if musc spasticity is especially discussed   
See Also Spasm 		Other names Clasp-Knife Spasticity; Spasticity, Muscle; Spasticity, Clasp-Knife; Clasp Knife Spasticity; Spastic
 
SubstanceCAS Registry & nameCategoriesSource
Powell Venencie Gordon syndrome  0   *Keratoderma, Palmoplantar *Muscle Spasticity.
Fitzsimmons Walson Mellor syndrome  0   *Glomerulonephritis, IGA *Hearing Loss, Sensorineural *Intellectual Disability *Muscle Spasticity *Spastic Paraplegia, Hereditary.
Seemanova Lesny syndrome  0   *Abnormalities, Multiple *Cataract/congenital *Growth Disorders *Hypogonadism *Intellectual Disability *Microcephaly *Muscle Spasticity.
Methylenetetrahydrofolate reductase deficiency  0   *Homocystinuria *Muscle Spasticity Psychotic Disorders Methylenetetrahydrofolate Reductase (NADPH2)/deficiency.
Koone Rizzo Elias syndrome  0   *Ichthyosis *Intellectual Disability *Muscle Spasticity.
Spastic ataxia Charlevoix-Saguenay type  0   *Muscle Spasticity *Spinocerebellar Ataxias/congenital.
Wells Jankovic syndrome  0   *Adrenoleukodystrophy *Deafness *Muscle Spasticity *Paralysis *Genetic Diseases, X-Linked.

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Sources: NLM Medical Subject Headings, NIH UMLS, Drugs@FDA, FDA AERS original data copyright United States Government. No endorsement implied. Last modified 6/6/2012
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