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Mustard Compounds

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Definition: Strong alkylating and immunosuppressive agents whose biological activity is based on the presence of bis(2-chloroethyl)- groups. Although otherwise structurally diverse, the compounds have in common the capacity to contribute alkyl groups to DNA. They are generally highly toxic but include among their number many widely used and effective antineoplastic agents.  DF: MUSTARD CPDS   
Examples Mustard Gas; Nitrogen Mustard Compounds 		Other names Compounds, Mustard
 
SubstanceCAS Registry & nameCategoriesSourceDrugs*
2-amino-3-(4'-N,N-bis(2-chloroethyl)amino)phenylpropionic acid N-oxide  0   *Mustard Compounds *Phenylpropionates. Mol Cancer Ther 2004 Mar;3(3):233-44
10-carboxydecyl-2-chloroethylsulfide  0   *Mustard Compounds. Toxicology 1996 Apr 15;108(1-2):125-8
4-carboxybutyl-2-chloroethylsulfide  0   *Mustard Compounds. Toxicology 1996 Apr 15;108(1-2):125-8
N-(2-chloroethyl)-N-nitrosocarbamoylglycinamide  80687-06-5   *Mustard Compounds *Nitrosourea Compounds. Mutat Res 1988;206(4):459
Cloturin  104789-46-0   *Mustard Compounds 6-Mercaptopurine/*analogs & derivatives. Cesk Farm 1988;37(6):246
N-(2-chloroethyl)-N-nitrosocarbamoylvalinamide  81965-44-8   *Mustard Compounds *Nitrosourea Compounds. J Med Chem 1988;31(8):1492
4(N)-(2-chloroethyl-N-methylamino)benzylamine  36665-43-7 benzenemethanamine, 4-((2-chloroethyl)methylamino)  *Mustard Compounds. Mol Biol (Mosk) 1980;14(3):531
bipiperidyl mustard  6802-93-3 1,1'-bis(beta-chloroethyl)-4,4'-bipiperidine  *Mustard Compounds. Endocrinol 97(6):1396;1975; Proc Nutr Soc 1979;38(3):107A
S-176 mustard  870-05-3 N,N'-ethylenebis((2-chloroethylthio)acetamide)  *Mustard Compounds.
N,N'-ethylenebis(5-(2-bromoethylthio)valeramide)  870-03-1   *Mustard Compounds. J Pharmacol Exp Ther 182(1):77;1972
2'-chloro-2'-cyanoethyl-1-thio-beta-D-galactopyranoside  36373-29-2 Propanenitrile, 2-chloro-3-(beta-D-galactopyranosylthio)  *Mustard Compounds. Nature (New Biology) 234(49):183;1971

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Sources: NLM Medical Subject Headings, NIH UMLS, Drugs@FDA, FDA AERS original data copyright United States Government. No endorsement implied. Last modified 6/6/2012
Warning: the drugs or drug combinations referred to here may be similar or related, but are not be the same ones and may not have the same pharmacological action as other substances described on the same page or in the same row. Please refer to product monograph or to your doctor
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