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Nicotinamide-Nucleotide Adenylyltransferase

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Definition: An enzyme that catalyzes reversibly the transfer of the adenylyl moiety of ATP to the phosphoryl group of NMN to form NAD+ and pyrophosphate. The enzyme is found predominantly in the nuclei and catalyzes the final reaction in the major pathway for the biosynthesis of NAD in mammals. EC 2.7.7.1.  DF: note short X ref    Other names Nicotinamide Mononucleotide Adenylyltransferase; NMN Adenylyltransferase; NAD Pyrophosphorylase; Nicotinamide Nucleotide Adenylyltransferase; Pyrophosphorylase, NAD; Mononucleotide Adenylyltransferase, Nicotinamide; Adenylyltransferase, Nicotinamide-Nucleotide; Adenylyltransferase, Nicotinamide Mononucleotide; Adenylyltransferase, NMN; Adenylyltransferase, ATP-NMN; ATP NMN Adenylyltransferase; ATP-NMN Adenylyltransferase
 
SubstanceCAS Registry & nameCategoriesSourceDrugs*
NMNAT3 protein, rat  EC 2.7.7.1   *Nicotinamide-Nucleotide Adenylyltransferase. J Neurosci 2008 May 7;28(19):4861-71
NMNAT1 protein, rat  EC 2.7.7.1   *Nicotinamide-Nucleotide Adenylyltransferase. J Neurosci 2008 May 7;28(19):4861-71
Nmnat1 protein, mouse  EC 2.7.7.1   *Nicotinamide-Nucleotide Adenylyltransferase. J Biol Chem 2004 Dec 3;279(49):50754-63
NMNAT3 protein, human  EC 2.7.7.1   *Nicotinamide-Nucleotide Adenylyltransferase.
NMNAT2 protein, human  EC 2.7.7.1   *Nicotinamide-Nucleotide Adenylyltransferase.
NMNAT1 protein, human  EC 2.7.7.1   *Nicotinamide-Nucleotide Adenylyltransferase.
Nmnat protein, mouse  EC 2.7.7.-   *Nicotinamide-Nucleotide Adenylyltransferase. Proc Natl Acad Sci U S A 2000 Oct 10;97(21):11377-82
SLR0787 protein, Synechocystis  EC 2.7.7.1   *Bacterial Proteins *Nicotinamide-Nucleotide Adenylyltransferase *Pyrophosphatases. FEBS Lett 1999 Feb 12;444(2-3):222-6
nicotinic acid mononucleotide adenylyltransferase  EC 2.7.7.18   *Nicotinamide-Nucleotide Adenylyltransferase Bacterial Proteins Escherichia coli Proteins. Biochem J 2004 Jan 15;377(Pt 2):317-26; J Bacteriol 1983;155(1):213

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Sources: NLM Medical Subject Headings, NIH UMLS, Drugs@FDA, FDA AERS original data copyright United States Government. No endorsement implied. Last modified 6/6/2012
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