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Nomifensine

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Definition: An isoquinoline derivative that prevents dopamine reuptake into synaptosomes. The maleate was formerly used in the treatment of depression. It was withdrawn worldwide in 1986 due to the risk of acute hemolytic anemia with intravascular hemolysis resulting from its use. In some cases, renal failure also developed. (From Martindale, The Extra Pharmacopoeia, 30th ed, p266)     
Pharmacological Action Dopamine Uptake Inhibitors 		Other names Maleate, Nomifensine; Hoe984; Hoe 984; Nomifensine Maleate (1:1); Nomifensine Maleate; Nomifensin; Merital; Linamiphen; Hoe-984
 
SubstanceCAS Registry & nameCategoriesSourceDrugs*
4-hydroxy-2-methyl-4-phenyl-1,2,3,4-tetrahydroisoquinoline  113258-90-5   Nomifensine/*analogs & derivatives. Br J Pharmacol 1988;94(1):19
3'-hydroxy-4'-methoxynomifensine  60520-18-5   Nomifensine/*analogs & derivatives. J Chromatogr 1985;341(2):333
4'-hydroxy-3'-methoxynomifensine  62080-80-2   Nomifensine/*analogs & derivatives. J Chromatogr 1985;341(2):333
4'-hydroxynomifensine  55774-26-0   Nomifensine/*analogs & derivatives. J Chromatogr 1985;341(2):333
psyton  75963-47-2   *Benzodiazepines *Nomifensine Drug Combinations. Wien Med Wochenschr 1982;132(8):183
3',4'-dihydroxynomifensine  69275-19-0 1,2-benzenediol,4-(8-amino-1,2,3,4-tetrahydro-2-methyl-4-isoquinolinyl)  Nomifensine/*analogs & derivatives. J Pharm Pharmacol 1980;32(3):225

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Sources: NLM Medical Subject Headings, NIH UMLS, Drugs@FDA, FDA AERS original data copyright United States Government. No endorsement implied. Last modified 6/6/2012
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