Nonsuppressible Insulin-Like Activity (definition)

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ψ	Nonsuppressible Insulin-Like Activity

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Definition: A blood protein (NSILA) which mimics the biological activity of insulin in serum, but is not suppressed by insulin antibodies. During acid-ethanol extraction of Cohn fraction III, 10% of the activity is found in the supernatant (NSILA-S) and the remaining activity in the precipitate (NSILA-P). The latter is a large molecular compound, much less stable than the soluble fraction. NSILA-S is a more potent growth factor than insulin and exhibits sulfation activity.

note category; a blood protein mimicking blood insulin

Other names NSILA-S; NSILA-P; NSILA; Nonsuppressible Insulin Like Activity; Insulinlike Activity, Nonsuppressible; Insulin-Like Activity, Nonsuppressible; Activity, Nonsuppressible Insulinlike; Activity, Nonsuppressible Insulin-Like; Nonsuppressible Insulinlike Activity

Substance	CAS Registry & name	Categories	Source	Drugs*
nonsuppressible insulin-like carrier protein, human	0	*Carrier Proteins Nonsuppressible Insulin-Like Activity.	Int J Biochem 1985;17(9):1003

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Sources: NLM Medical Subject Headings, NIH UMLS, Drugs@FDA, FDA AERS original data copyright United States Government. No endorsement implied. Last modified 6/6/2012
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