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Phenformin

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Definition: A biguanide hypoglycemic agent with actions and uses similar to those of METFORMIN. Although it is generally considered to be associated with an unacceptably high incidence of lactic acidosis, often fatal, it is still available in some countries. (From Martindale, The Extra Pharmacopoeia, 30th ed, p290)     
Pharmacological Action Hypoglycemic Agents 		Other names Fenformin; Phenylethylbiguanide
 
SubstanceCAS Registry & nameCategoriesSourceDrugs*
4-hydroxyphenformin  17426-94-7   Phenformin/*analogs & derivatives. J Pharm Pharmacol 1980;32(10):731
tolbutaphen  78939-99-8 Benzenesulfonamide, N-((butylamino)carbonyl)-4-methyl-, mixt. with N-(2-phenylethyl)imidodicarbonimidic diamide  *Phenformin *Tolbutamide Drug Combinations. Z Allgemeinmed 51(2):74;1975
phenethylguanidine  538-69-2   Phenformin/*analogs & derivatives. Tohoku J Exp Med 111(1):1;1973
Suguan  52337-30-1   *Glyburide *Phenformin Drug Combinations. Clin Ter 63(4):337;1972

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Sources: NLM Medical Subject Headings, NIH UMLS, Drugs@FDA, FDA AERS original data copyright United States Government. No endorsement implied. Last modified 6/6/2012
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