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Phosphoenolpyruvate Carboxykinase (GTP)

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Definition: An enzyme of the lyase class that catalyzes the conversion of GTP and oxaloacetate to GDP, phosphoenolpyruvate, and carbon dioxide. This reaction is part of gluconeogenesis in the liver. The enzyme occurs in both the mitochondria and cytosol of mammalian liver. (From Dorland, 27th ed) EC 4.1.1.32.  do not confuse with PHOSPHOENOLPYRUVATE CARBOXYKINASE (ATP); DF: PEP CARBOXYKINASE GTP    Other names Phosphoenolpyruvate Carboxykinase, GTP-Dependent; GTP Dependent Phosphoenolpyruvate Carboxykinase; Carboxykinase, GTP-Dependent Phosphoenolpyruvate; GTP-Dependent Phosphoenolpyruvate Carboxykinase
 
SubstanceCAS Registry & nameCategoriesSourceDrugs*
Phosphoenolpyruvate carboxykinase deficiency  0   *Carbohydrate Metabolism, Inborn Errors *Liver Diseases Phosphoenolpyruvate Carboxykinase (GTP)/deficiency.
PCK1 protein, human  EC 4.1.1.32   *Phosphoenolpyruvate Carboxykinase (GTP) *Intracellular Signaling Peptides and Proteins. Am J Med Genet B Neuropsychiatr Genet. 2007 Jun 5;144(4):508-16
phosphoenolpyruvate carboxykinase ferroactivator protein, rat  0   *Glutathione Peroxidase Enzyme Activation Phosphoenolpyruvate Carboxykinase (GTP). Biol Neonate 1979;36(5-6):311; J Biol Chem 252(1):116;1977; J Biol Chem 252(4):1431;1977
3-mercaptopicolinic acid  14623-54-2   *Picolinic Acids Phosphoenolpyruvate Carboxykinase (GTP)/antagonists & inhibitors.
Pharma Action Enzyme Inhibitors 		Biochem Biophys Res Commun 1979;90(3):741; Biochem Biophys Res Commun 87(1):155;1979; Biochem J 138(3):387;1974; Biochem J 170:699;1978; Biochem J 174(1):131;1978; Biochem J 1980;186(1):317; Biochim Biophys Acta 1979;586(2):242; Biochim Biophys Acta 526(1):293;1978; Biochim Biophys Acta 542(1):1;1978; Clin Sci 1979;57(1):105; FEBS Lett 58(1):12;1975; Gen Comp Endocrinol 34:243;1978; J Biol Chem 251(18):5824;1976; J Biol Chem 254(6):1875;1979; J Med Chem 20(4):572;1977; J Protozool 23(3):473;1976; Proc Sixth Int Congr Nephrol W3IN 446:179;1975a

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Sources: NLM Medical Subject Headings, NIH UMLS, Drugs@FDA, FDA AERS original data copyright United States Government. No endorsement implied. Last modified 6/6/2012
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