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Physostigmine

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Definition: A cholinesterase inhibitor that is rapidly absorbed through membranes. It can be applied topically to the conjunctiva. It also can cross the blood-brain barrier and is used when central nervous system effects are desired, as in the treatment of severe anticholinergic toxicity.     
Pharmacological Action Cholinesterase Inhibitors; Miotics 		Other names Eserine
 
SubstanceCAS Registry & nameCategoriesSourceDrugs*
tetrahydrofurobenzofuran cymserine  0   Physostigmine/*analogs & derivatives. J Neural Transm 2008 Jun;115(6):889-98
dihydrobenzodioxepine cymserine  0   *Benzoxepins Physostigmine/analogs & derivatives. Neurochem Res 2008 May;33(5):745-53
N(1)-phenethylnorcymserine  0   Physostigmine/*analogs & derivatives Butyrylcholinesterase. Eur J Pharmacol 2007 Oct 31;572(2-3):142-50
esermethole  0   Physostigmine/*analogs & derivatives. Chemistry. 2007;13(3):961-7
bisnorcymserine  0   Physostigmine/*analogs & derivatives. J Alzheimers Dis. 2006 Sep;10(1):43-51
cymserine  0   Physostigmine/*analogs & derivatives. Biochim Biophys Acta 2006 Feb;1760(2):200-6
tolserine  0   Physostigmine/*analogs & derivatives. Biochem Pharmacol 2000 Aug 15;60(4):561-70
N(1),N(8)-bisnorphysostigmine  0   Physostigmine/*analogs & derivatives. J Med Chem 1998 Jun 18;41(13):2371-9
N(1),N(8)-bisnorphenserine  0   Physostigmine/*analogs & derivatives. J Med Chem 1998 Jun 18;41(13):2371-9
N(8)-norphenserine  0   Physostigmine/*analogs & derivatives. J Med Chem 1997 Aug 29;40(18):2895-901
N(8)-norphysostigmine  0   Physostigmine/*analogs & derivatives. J Med Chem 1997 Aug 29;40(18):2895-901
physovenine  6091-05-0   Physostigmine/*analogs & derivatives. Med Res Rev 1995 Jan;15(1):3-31
phenserine  0   Physostigmine/*analogs & derivatives. Psychopharmacology (Berl) 1993;112(4):415-20
1-methylphysostigmine  121843-39-8   Physostigmine/*analogs & derivatives. J Pharmacol Exp Ther 1993 Jun;265(3):1474-91
physostigmine heptyl  101246-68-8   Physostigmine/*analogs & derivatives.
Pharma Action Cholinesterase Inhibitors 		Pharmacol Biochem Behav 1987;26(3):625
physostigmine methiodide  6091-11-8 Pyrrolo(2,3-b)indolium, 1,2,3,3a,8,8a-hexahydro-1,1,3a,8(or 1,3a,8,8)-tetramethyl-5-(((methylamino)carbonyl)oxy)-, iodide, (3aS-cis)  Physostigmine/*analogs & derivatives. Mol Pharmacol 1985;28(6):527
rubreserine  18455-27-1   Physostigmine/*analogs & derivatives. J Chromatogr 1980;198(4):529
physostigmine salicylate  57-64-7   Physostigmine/*analogs & derivatives. Ugeskr Laeger 1980;142(18):1149
vagoserine  78891-93-7 L-Glutamic acid, hydrochloride, mixt. with (4aS-cis)-2,3,4,4a,9,9a-hexahydro-2,4a,9-trimethyl-1,2-oxazino(6,5-b)indol-6-yl methylcarbamate mono(2-hydroxybenzoate) and papain  *Glutamates *Papain Drug Combinations Physostigmine/*analogs & derivatives. Med Chir Dig 8(6):577;1979
eserine amine oxide  0   Physostigmine/*analogs & derivatives. Biomed 28(1):35;1978
thioeserine  61562-64-9 Carbamothioic acid, methyl-, S-(1,2,3,3a,8,8a-hexahydro-1,3a,8-trimethylpyrrolo(2,3-b)indol-5-yl) ester, (3aS-cis)  Physostigmine/*analogs & derivatives. Arch Pharm 309(8):631;1976
physostigmine-N-oxide  0   Physostigmine/*analogs & derivatives. Rev Stomatol Chir Maxillofac 75(7):995;1974

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Sources: NLM Medical Subject Headings, NIH UMLS, Drugs@FDA, FDA AERS original data copyright United States Government. No endorsement implied. Last modified 6/6/2012
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