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DNA Ligases

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Definition: Poly(deoxyribonucleotide):poly(deoxyribonucleotide)ligases. Enzymes that catalyze the joining of preformed deoxyribonucleotides in phosphodiester linkage during genetic processes during repair of a single-stranded break in duplex DNA. The class includes both EC 6.5.1.1 (ATP) and EC 6.5.1.2 (NAD).  do not confuse X ref POLYDEOXYRIBONUCLEOTIDE SYNTHETASES with X ref POLYRIBONUCLEOTIDE SYNTHETASE    Other names Polydeoxyribonucleotide Synthetases; Polydeoxyribonucleotide Ligases; DNA Joinases; Synthetases, Polydeoxyribonucleotide; Ligases, Polydeoxyribonucleotide; Ligases, DNA; Ligase, T4 DNA; Joinases, DNA; DNA Ligase, T4; T4 DNA Ligase
 
SubstanceCAS Registry & nameCategoriesSourceDrugs*
LIG6 protein, Arabidopsis  EC 6.5.1.-   *DNA Ligases *Arabidopsis Proteins. Plant J 2010 Sep;63(5):848-60
Lig4 protein, Arabidopsis  EC 6.5.1.-   *DNA Ligases. Nucleic Acids Res 2007;35(19):6490-500
LigA protein, E coli  EC 6.5.1.2   *DNA Ligases *Escherichia coli Proteins. Microbiology. 2004 Dec;150(Pt 12):4171-80
DNA ligase D, Mycobacterium tuberculosis  EC 6.5.1.-   *DNA Ligases. Science 2004 Oct 22;306(5696):683-5
Cdc17 protein, S pombe  EC 6.5.1.1   *DNA Ligases *Schizosaccharomyces pombe Proteins. Nucleic Acids Res 2004;32(2):632-42
DRT111 protein, Arabidopsis  EC 6.5.1.-   *DNA Ligases *Arabidopsis Proteins. Eur J Biochem 2002 Jul;269(14):3393-401
DNA repair enzyme TgDRE, Toxoplasma gondii  EC 6.5.1.-   *DNA Ligases *Protozoan Proteins. Eur J Biochem 2002 Jul;269(14):3393-401
Rep75 protein, Pyrococcus abyssi  0   *Nucleotidyltransferases *DNA Ligases *Archaeal Proteins. Mol Microbiol 1999 Aug;33(3):537-45
ATP-dependent capping enzyme, chimeric  0   *Nucleotidyltransferases *DNA Ligases *Recombinant Fusion Proteins. Nucleic Acids Res 1999 Aug 15;27(16):3253-8
DNA ligase (NAD)  EC 6.5.1.2   *DNA Ligases. Biochim Biophys Acta 1999 Jul 13;1432(2):413-8
Chlorella virus DNA ligase  EC 6.5.1.-   *DNA Ligases *Viral Proteins. Nucleic Acids Res 1998 Jan 15;26(2):525-31
RC-1 recombination protein complex  0   *DNA-Directed DNA Polymerase *Endodeoxyribonucleases *Multienzyme Complexes *DNA Ligases. EMBO J 1996 Aug 1;15(15):4061-8
Ampligase  EC 6.5.1.-   *DNA Ligases. Mutat Res 1992 Oct;283(2):119-23
DNA ligase III  EC 6.5.1.-   *DNA Ligases Xenopus Proteins. J Biol Chem 1991;266(32):21728
DNA ligase (ATP)  EC 6.5.1.1   *DNA Ligases Saccharomyces cerevisiae Proteins. J Biol Chem 1986;261(15):6888

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Sources: NLM Medical Subject Headings, NIH UMLS, Drugs@FDA, FDA AERS original data copyright United States Government. No endorsement implied. Last modified 6/6/2012
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