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RNA Ligase (ATP)

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Definition: An enzyme that catalyzes the conversion of linear RNA to a circular form by the transfer of the 5'-phosphate to the 3'-hydroxyl terminus. It also catalyzes the covalent joining of two polyribonucleotides in phosphodiester linkage. EC 6.5.1.3.  do not confuse X ref POLYRIBONUCLEOTIDE SYNTHETASE with X refs POLYDEOXYRIBONUCLEOTIDE SYNTHETASES or POLYNUCLEOTIDE SYNTHETASES    Other names Polyribonucleotide Synthetase; Synthetase, Polyribonucleotide; Ligase, tRNA; tRNA Ligase
 
SubstanceCAS Registry & nameCategoriesSourceDrugs*
RtcB protein, Methanopyrus kandleri  EC 6.5.1.3   *RNA Ligase (ATP) *Archaeal Proteins. Proc Natl Acad Sci U S A. 2011 Jan 25;108(4):1290-5
Trl1 protein, S cerevisiae  EC 6.5.1.3   *RNA Ligase (ATP) *Saccharomyces cerevisiae Proteins. Nucleic Acids Res. 2006;34(2) (dup#4):517-27
bacteriophage T4 RNA ligase 1  EC 6.5.1.3   *RNA Ligase (ATP) *Viral Proteins. J Biol Chem 2003 Aug 8;278(32):29454-62
bacteriophage T4 RNA ligase 2  EC 6.5.1.3   *RNA Ligase (ATP) *Viral Proteins. Proc Natl Acad Sci U S A 2002 Oct 1;99(20):12709-14
tRNA splicing ligase  EC 6.5.1.-   *RNA Ligase (ATP) RNA Splicing. Biochem Biophys Res Commun 1997 Aug 28;237(3):588-94
tRNA excision ligase  EC 6.5.1.-   *RNA Ligase (ATP). Nature 274(3):438;1978

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