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Pregnadienediols

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Definition: Doubly unsaturated pregnane derivatives with two hydroxy groups substituted anywhere on the rings or side chains.     
Examples Desoximetasone; Fluocortolone; Fluorometholone; Prednisone 		Other names Dihydroxypregnadienes
 
SubstanceCAS Registry & nameCategoriesSourceDrugs*
3,21-dihydroxypregna-5,7-dien-20-one  0   *Pregnadienediols. Steroids 2011 Jan;76(1-2):193-203
dulera  0   *Ethanolamines *Pregnadienediols Drug Combinations. Med Lett Drugs Ther 2010 Oct 18;52(1349):83-4DULERA
11beta,17alpha-dihydroxy-21-methylpregna-4-diene-3,20-dione-17-butyrate  0   *Pregnadienediols. J Vet Pharmacol Ther 2004 Oct;27(5);309-15
pregna-4,9(11)-diene-17alpha,21-diol-3,20-dione acetates  0   *Pregnadienediols. Steroids. 2003 May;68(5):415-21
(20S)-20-(N,N-dimethylamino)-3beta-methoxy-pregn-5,16-diene  0   *Pregnadienediols. Nat Prod Res. 2003 Aug;17(4):235-41
(20S)-20-(N,N-dimethylamino)-3beta-(tigloylamino)-5alpha-pregn-14-en-2beta,4beta-diol  0   *Pregnadienediols Alkaloids. Nat Prod Res. 2003 Aug;17(4):235-41
anecortave acetate  0   *Pregnadienediols Angiogenesis Inhibitors. Invest Ophthalmol Vis Sci 2001 Jan;42(1):283-90
methyl 21-acetyloxy-3,20-dioxo-11,17-dihydroxy-9-fluoro-1,4-pregnadiene-16-carboxylate  0   *Pregnadienediols. Steroids 1997 Jun;62(6):491-9
clogestone  20047-75-0 6-chloro-3beta,17-dihydroxypregna-4,6-dien-20-one  *Pregnadienediols Progesterone Congeners.
20-(3-hydroxy-3-methylbutyloxy)pregna-5,7-diene-1,3-diol  142785-61-3   *Pregnadienediols Tritium. Steroids 1992 Sep;57(9):444-6
mometasone furoate  83919-23-7   *Pregnadienediols.
Pharma Action Anti-Inflammatory Agents ; Anti-Allergic Agents 		Med Lett Drugs Ther 1987;29(751):96ELOCON; NASONEX; MOMETASONE FUROATE; ASMANEX TWISTHALER
11,20-dihydroxy-3-oxopregna-4,17(20)-dien-21-al  3247-38-9   *Pregnadienediols. Endocrinology 1986;119(3):1356
Win 44577  98640-98-3 2'H-Pregna-2,4-dien-20-yno(3,2-c)pyrazole-11,17-diol, 2'-(4-fluorophenyl)-, (11beta,17alpha)  *Pregnadienediols. Steroids 1984;44(5):447
fluodexan  95017-33-7 Pregna-1,4-diene-3,20-dione, 21,21'-(methylenebis((2-methoxy-1,3-naphthalenediyl)carbonyloxy))bis(9-fluoro-11-hydroxy-16,17-((1-methylethylidene)bis(oxy))-, (11beta,16alpha)-(11'beta,16'alpha)-, mixt. with urea  *Urea *Pregnadienediols Drug Combinations. Z Hautkr 1984;59(3):157
cyclomethasone  86022-88-0   *Pregnadienediols. G Ital Dermatol Venereol 1983;118(1):XV
mepregenol diacetate  3116-07-2   *Pregnadienediols. Farmikol Toksikol 1980;43(2):196
7 alpha,12 alpha-dihydroxy-3-oxopregna-1,4-diene-20-carboxylic acid  70643-61-7 (7 alpha,12 alpha)-7,12-dihydroxy-3-oxopregna-1,4-diene-20-carboxylic acid  *Pregnadienediols. Biochem J 1979;184(3):613
oxazacort  74712-90-6 4'H-Pregna-1,4-dieno(16,17-d)oxazole-3,20-dione, 21-(acetyloxy)-11-hydroxy-2'-methyl-, (11beta,16beta)  *Pregnadienediols. Int J Clin Pharm Biopharm 15(3):126;1977
flupamesone  55461-42-2 4,4'-Methylene-bis(9 alpha-fluor-11 beta, 21-dihydroxy-16 alpha,17 alpha-iso- propylidenedioxy-1,4-pregnadiene-3,20 dione)3-methoxy-2- naphthoatel  *Pregnadienediols. Actas Dermo-Sifiliograt 68(1-2):83;1977; Arzneimittelforsch 25(7):1040;1975; Cur Ther Res 21(2):183;1977; Rev Clin Esp 142(3):255;1976; Rev Clin Espan 149(5):492;1978
diendiol  3494-53-9 Pregna-4,17(20)-dien-3-one, 11,21-dihydroxy-, (11beta)  *Pregnadienediols. Acta Microbiol 22(4):509;1975; Hoppe Seyler Z Physiol Chem 355(10):1176;1974
GR 2-2132  52468-90-3 6,11 beta-dichloro-3 beta,17-dihydroxy-19-nor-4, 6-pregnadien-20-one-17-acetate-3 beta-benzoate  *Pregnadienediols Progesterone Congeners. Steroids 24(5):731;1974
fluazacort  19888-56-3 5'H-pregna-1,4-dieno(17,16-d)oxazole-3,20-dione, 21-(acetyloxy)-9-fluoro-11-hydroxy-2'-methyl-, (11 beta,16 beta)  *Pregnadienediols. Arzneim Forsch 25(10):1650;1975; G Batteriol Virol Immunol 70(1-6):95;1977; Hautarzt 24(12):555;1974
tralonide  21365-49-1 (6 alpha, 11 beta,16 alpha)-9,11-dichloro-6,21-difluoro- 16,17-((1-methylethylidene)bis(oxy))pregna-1,4- diene-3,20-dione  *Pregnadienediols. Curr Ther Res 13(9):595;1971
16 alpha-methyldichlorosone-17,21-dibutyrate  10549-91-4   *Pregnadienediols.
16-alpha-methyldichlorosone  4732-48-3   *Pregnadienediols. Steroids 21(3):443;1973

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Sources: NLM Medical Subject Headings, NIH UMLS, Drugs@FDA, FDA AERS original data copyright United States Government. No endorsement implied. Last modified 6/6/2012
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