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Probenecid

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Definition: The prototypical uricosuric agent. It inhibits the renal excretion of organic anions and reduces tubular reabsorption of urate. Probenecid has also been used to treat patients with renal impairment, and, because it reduces the renal tubular excretion of other drugs, has been used as an adjunct to antibacterial therapy.     
Pharmacological Action Adjuvants, Pharmaceutic; Uricosuric Agents
Other names Probenecid Zenith Brand; Probenecid Parmed Brand; Probenecid Martec Brand; Probenecid Major Brand; Zenith Brand of Probenecid; Valdecasas Brand of Probenecid; Probenecid Weimer; Probecid; Pro-Cid; Parmed Brand of Probenecid; Ophthalmic Brand of Probenecid; Merck Brand of Probenecid; Martec Brand of Probenecid; Major Brand of Probenecid; IDIS Brand of Probenecid; ICN Brand of Probenecid; Biokanol Brand of Probenecid; Benuryl; Benemid; BenecidDrugs* : PROBENECID; PROBALAN; PROBENECID W/ COLCHICINE; BENEMID; PROBEN-C; PROBENECID AND COLCHICINE; COL-PROBENECID; COLBENEMID
 
SubstanceCAS Registry & nameCategoriesSourceDrugs*
4-((diethylamino)sulfonyl)benzoic acid  1213-06-5   Probenecid/*analogs & derivatives. Vestn Dermatol Venerol 1985;(9):12
prototapen  80042-41-7 4-Thia-1-azabicyclo(3.2.0)heptane-2-carboxylic acid, 6-((aminophenylacetyl)amino)-3,3-dimethyl-7-oxo-, (2S-(2alpha,5alpha,6beta(S*)))-, mixt. with 4-((dipropylamino)sulfonyl)benzoic acid  *Ampicillin *Probenecid Drug Combinations. Arch Inst Pasteur Madagascar 1980;47(1):65
2-nitroprobenecid  2577-52-8 4-((dipropylamino)sulfonyl)-2-nitrobenzoic acid  Probenecid/*analogs & derivatives. J Pharmacol Exp Ther 210(2):186;1979
pivampicillin probenate  42190-91-0 (2S-(2 alpha,5 alpha,6 beta(S*)))-6-((aminophenylacetyl)amino)-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo(3.2.0)heptane-2-carboxylic acid, (2,2-dimethyl-1-oxopropoxy)methyl ester, mono(4-((dipropylamino)sulfonyl)benzoate)  *Pivampicillin *Probenecid Drug Combinations. Eur J Clin Pharmacol 9(2/3):125;1975

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Sources: NLM Medical Subject Headings, NIH UMLS, Drugs@FDA, FDA AERS original data copyright United States Government. No endorsement implied. Last modified 6/6/2012

Warning: the drugs or drug combinations referred to here may be similar or related, but are not be the same ones and may not have the same pharmacological action as other substances described on the same page or in the same row. Please refer to product monograph or to your doctor
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