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Complement Factor D

More information in Books or onNLM PubMed
Definition: A serum protein which is important in the ALTERNATIVE COMPLEMENT ACTIVATION PATHWAY. This enzyme cleaves the COMPLEMENT C3B-bound COMPLEMENT FACTOR B to form C3bBb which is ALTERNATIVE PATHWAY C3 CONVERTASE.  see SCR for organism-specific terms   
Pharmacological Action Immunologic Factors
Other names Properdin Factor D; Factor D; C3PA Convertase; C3 Convertase Activator; Adipsin; Protein D, Complement; Factor D, Properdin; Factor D, Complement; Convertase, Proactivator; Convertase, C3PA; Convertase, C3 Proactivator; Convertase Activator, C3; Complement D Component; Activator, C3 Convertase; Proactivator Convertase; GBGase; D Component of Complement; Complement Protein D; C3PAse; C3 Proactivator Convertase
 
SubstanceCAS Registry & nameCategoriesSourceDrugs*
complement factor D, mouse  EC 3.4.21.46   Complement Factor D.
complement factor D, human  EC 3.4.21.46   Complement Factor D.
BCX 1470  0   *Thiophenes Complement Factor D/antagonists & inhibitors Thiophenes. J Immunol 2000 Jan 1;164(1):463-8

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Sources: NLM Medical Subject Headings, NIH UMLS, Drugs@FDA, FDA AERS original data copyright United States Government. No endorsement implied. Last modified 6/6/2012

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