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gamma-Glutamyl Hydrolase

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Definition: Catalyzes the hydrolysis of pteroylpolyglutamic acids in gamma linkage to pterolylmonoglutamic acid and free glutamic acid. EC 3.4.19.9.      Other names Pteroyl Polyglutamate Hydrolase; Folyl Conjugate Synthetase; Folate Conjugase; Conjugase; gamma Glutamyl Hydrolase; Folylpolyglutamate Hydrolase; Folyl Polyglutamate Cleavage Enzyme; Folyl Poly-gamma-Glutamate Carboxypeptidase; Folate Hydrolyzing Enzyme; Folacin Conjugase; Carboxypeptidase G2; Carboxypeptidase G1; Carboxypeptidase GDrugs* : VORAXAZE
 
SubstanceCAS Registry & nameCategoriesSourceDrugs*
p-aminobenzoyl-glutamate hydrolase, E coli  EC 3.4.19.9   *gamma-Glutamyl Hydrolase. J Bacteriol. 2010 May;192(9):2407-13
N(alpha)-(5-deaza-5,6,7,8-tetrahydropteroyl)ornithine  141397-59-3   Folic Acid/*analogs & derivatives gamma-Glutamyl Hydrolase/antagonists & inhibitors. J Med Chem 1992 May 29;35(11):2002-6
2-mercaptomethylglutaric acid  106146-19-4   *Glutarates gamma-Glutamyl Hydrolase/antagonists & inhibitors. Biochem Biophys Res Commun 1987;144(1):292

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Sources: NLM Medical Subject Headings, NIH UMLS, Drugs@FDA, FDA AERS original data copyright United States Government. No endorsement implied. Last modified 6/6/2012
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