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Pyroglobulins

More information in Books or onNLM PubMed
Definition: Atypical gamma immunoglobulins characterized by their irreversible heat denaturation at 56-degrees C. Pyroprecipitation is inhibited at pH below 3 and above 9. The presence of pyroglobulins in the serum is the cause of pyroglobulinemia. They are frequently present in multiple myeloma and the pyroglobulin precipitate binds complement, reacts with rheumatoid factor, produces passive cutaneous anaphylaxis, generalized passive anaphylaxis and passive Arthus-type phenomena.     
Pharmacological Action Immunologic Factors
 
SubstanceCAS Registry & nameCategoriesSourceDrugs*
IgD pyroglobulin  0   *Immunoglobulin D *Pyroglobulins. Clin Chim Acta 1986;160(3):235
pyrogel  0   *Pyroglobulins. Am J Med 61(3):321;1976

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Sources: NLM Medical Subject Headings, NIH UMLS, Drugs@FDA, FDA AERS original data copyright United States Government. No endorsement implied. Last modified 6/6/2012
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