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Pyrroline Carboxylate Reductases

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Definition: A group of enzymes that catalyze the reduction of 1-pyrroline carboxylate to proline in the presence of NAD(P)H. Includes both the 2-oxidoreductase (EC 1.5.1.1) and the 5-oxidoreductase (EC 1.5.1.2). The former also reduces 1-piperidine-2-carboxylate to pipecolate and the latter also reduces 1-pyrroline-3-hydroxy-5-carboxylate to hydroxyproline.      Other names Reductases, Pyrroline Carboxylate; Carboxylate Reductases, Pyrroline
 
SubstanceCAS Registry & nameCategoriesSourceDrugs*
pyrroline-5-carboxylate reductase, M tuberculosis  EC 1.5.1.2   *Pyrroline Carboxylate Reductases. Protein Expr Purif. 2006 Jan;45(1):241-8
delta-1-pyrroline-5-carboxylate reductase  EC 1.5.1.2   *Pyrroline Carboxylate Reductases Arabidopsis Proteins Saccharomyces cerevisiae Proteins Escherichia coli Proteins. Comp Biochem Physiol B. 1979;62(2):143-6; Mol Gen Genet 1992 Aug;234(2):193-200

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Sources: NLM Medical Subject Headings, NIH UMLS, Drugs@FDA, FDA AERS original data copyright United States Government. No endorsement implied. Last modified 6/6/2012
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