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Pyruvate Decarboxylase

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Definition: Catalyzes the decarboxylation of an alpha keto acid to an aldehyde and carbon dioxide. Thiamine pyrophosphate is an essential cofactor. In lower organisms, which ferment glucose to ethanol and carbon dioxide, the enzyme irreversibly decarboxylates pyruvate to acetaldehyde. EC 4.1.1.1.      Other names alpha-Ketoacid Carboxylase; alpha-Carboxylase; Pyruvic Decarboxylase; alpha Ketoacid Carboxylase; alpha Carboxylase; Decarboxylase, Pyruvate; Carboxylase, alpha-Ketoacid; Carboxy-Lyase, 2-Oxo Acid; Acid Carboxy-Lyase, 2-Oxo; Decarboxylase, Pyruvic; 2 Oxo Acid Carboxy Lyase; 2-Oxo Acid Carboxy-Lyase
 
SubstanceCAS Registry & nameCategoriesSourceDrugs*
Thi3 protein, S cerevisiae  0   *Carrier Proteins *Saccharomyces cerevisiae Proteins Pyruvate Decarboxylase. FEBS Lett 2008 Dec 10;582(29):3991-6
IAR4 protein, Arabidopsis  EC 4.1.1.1   *Pyruvate Decarboxylase *Arabidopsis Proteins. Plant Physiol 2004 Jun;135(2):989-99
PDC1 protein, S cerevisiae  EC 4.1.1.1   *Pyruvate Decarboxylase *Saccharomyces cerevisiae Proteins. Plant Mol Biol 1996 Jul;31(4):761-70
CFP protein, Neurospora crassa  EC 4.1.1.1   *Fungal Proteins *Microtubule-Associated Proteins *Pyruvate Decarboxylase Neurospora crassa. Genetics 1992Jul;131(3):575-80
4-(4-chlorophenyl)-2-oxo-3-butenoic acid  33185-97-6   *Fatty Acids, Monounsaturated Pyruvate Decarboxylase/antagonists & inhibitors. Biochemistry 1983;22(16):3735

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Sources: NLM Medical Subject Headings, NIH UMLS, Drugs@FDA, FDA AERS original data copyright United States Government. No endorsement implied. Last modified 6/6/2012
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