Genes (definition)

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ψ	Genes, ras

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Definition: Family of retrovirus-associated DNA sequences (ras) originally isolated from Harvey (H-ras, Ha-ras, rasH) and Kirsten (K-ras, Ki-ras, rasK) murine sarcoma viruses. Ras genes are widely conserved among animal species and sequences corresponding to both H-ras and K-ras genes have been detected in human, avian, murine, and non-vertebrate genomes. The closely related N-ras gene has been detected in human neuroblastoma and sarcoma cell lines. All genes of the family have a similar exon-intron structure and each encodes a p21 protein.

Other names v-Ki-ras Genes; v-Ha-ras Genes; ras Genes; c-N-ras Genes; c-Ki-ras Genes; c-Ha-ras Genes; N-ras Genes; Ki-ras Genes; Ha-ras Genes; v K ras Genes; v H ras Oncogenes; v H ras Genes; ras Oncogenes; ras Gene; c-N-ras Proto-Oncogene; c-N-ras Gene; c-Ki-ras Proto-Oncogene; c-Ki-ras Gene; c-K-ras Proto-Oncogene; c-K-ras Gene

Substance	CAS Registry & name	Categories	Source
Rras2 protein, mouse	EC 3.6.1	Membrane Proteins Monomeric GTP-Binding Proteins Genes, ras.
RRAS2 protein, human	EC 3.6.1	Membrane Proteins Monomeric GTP-Binding Proteins Genes, ras.	Mol Cell Biol 1994 Jun;14(6):4108-15

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Sources: NLM Medical Subject Headings, NIH UMLS, Drugs@FDA, FDA AERS original data copyright United States Government. No endorsement implied. Last modified 6/6/2012
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Genes, ras