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Rifampin

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Definition: A semisynthetic antibiotic produced from Streptomyces mediterranei. It has a broad antibacterial spectrum, including activity against several forms of Mycobacterium. In susceptible organisms it inhibits DNA-dependent RNA polymerase activity by forming a stable complex with the enzyme. It thus suppresses the initiation of RNA synthesis. Rifampin is bactericidal, and acts on both intracellular and extracellular organisms. (From Gilman et al., Goodman and Gilman's The Pharmacological Basis of Therapeutics, 9th ed, p1160)     
Pharmacological Action Antibiotics, Antitubercular; Enzyme Inhibitors; Leprostatic Agents; Nucleic Acid Synthesis Inhibitors 		Other names Rifampicin; Tubocin; Rimactane; Rimactan; Rifadin; BenemycinDrugs* : RIMACTANE; RIFADIN; RIFAMPIN
 
SubstanceCAS Registry & nameCategoriesSourceDrugs*
Myrin P  0   *Ethambutol *Isoniazid *Pyrazinamide *Rifampin Drug Combinations. Antibiot Khimioter 2002;47(6):22-7
rifamazid  0   *Isoniazid *Rifampin Drug Combinations. Pneumonol Alergol Pol 1998;66(3-4):198-206RIFAMATE; RIFAMPIN AND ISONIAZID
cotrifazid  0   *Isoniazid *Rifampin *Sulfamethoxazole *Trimethoprim Drug Combinations. Chemotherapy 1996 Nov-Dec;42(6):391-401
23-(O-ribofuranosyl)rifampicin  0   Rifampin/*analogs & derivatives. J Antibiot (Tokyo) 1995 Nov;48(11):1299-303
3-formyl-23-(O-ribofuranosyl)rifamycin SV  0   Rifampin/*analogs & derivatives. J Antibiot (Tokyo) 1995 Nov;48(11):1299-303
isoniazid, pyrazinamide, rifampin drug combination  0   *Isoniazid *Pyrazinamide *Rifampin Drug Combinations.
Pharma Action Antitubercular Agents 		Am Rev Respir Dis 1986 Jun:133(6):1076-80RIFATER
3-formyl-21-(O-phosphoryl)rifamycin SV  0   Rifampin/*analogs & derivatives. J Antibiot (Tokyo) 1993 Oct;46(10):1605-10
21-(O-phosphoryl)rifampicin  0   Rifampin/*analogs & derivatives. J Antibiot (Tokyo) 1993 Oct;46(10):1605-10
23-(O-(beta-glucopyranosyl))rifampicin  0   Rifampin/*analogs & derivatives. J Antibiot (Tokyo) 1993 Oct;46(10):1605-10
3-formyl-23-(O-(beta-glucopyranosyl))rifamycin SV  0   Rifampin/*analogs & derivatives. J Antibiot (Tokyo) 1993 Oct;46(10):1605-10
CGS 24565  136583-72-7   Rifampin/*analogs & derivatives. J Chromatogr 1993 Feb 26;612(2):310-4
CGP 43371  123036-23-7 Rifamycin, N,15-didehydro-15-deoxo-1-deoxy-1,15-epoxy-3-(4-((2,4,6-trimethylphenyl)methyl)-1-piperazinyl)-, 8-(2,2-dimethylpropanoate)  Rifampin/*analogs & derivatives. J Chromatogr 1993 Feb 26;612(2):310-4
rivicycline  130030-59-0   Rifampin Tetracycline. Gig Tr Prof Zabol 1990;(8):25
rifampicin N-oxide  51963-55-4   Rifampin/*analogs & derivatives. Farmaco Sci 1984;39(9):806
Sinerdol EH  0   Rifampin/*analogs & derivatives. Rev Ig (Pneumoftiziol) 1983;32(1):33
25-deacetylrifampicin  16783-99-6   Rifampin/*analogs & derivatives. J Chromatogr 1981;225(2):526
25-desacetylrifapentine  79039-56-8 Rifamycin, 3-(((4-cyclopentyl-1-piperazinyl)imino)methyl)-25-O-deacetyl  Rifampin/*analogs & derivatives. Farmaco (Prat) 1981;36(7):319
dehydrorifampicin  13983-13-6   Rifampin/*analogs & derivatives. Antibiotiki 1980;25(11):857
Rifaprim  61498-94-0 3-(((4-methyl-1-piperazinyl)imino)methyl)rifamycin, mixt. with 5-((3,4,5-trimethoxyphenyl) methyl)-2,4-pyrimidinediamine  *Rifampin *Trimethoprim Drug Combinations. J Int Med Res 7(2):132;1979
rifapentine  61379-65-5   Rifampin/*analogs & derivatives.
Pharma Action Antibiotics, Antitubercular ; Leprostatic Agents 		Br J Clin Pharm 6(5):455P;1978PRIFTIN
18,19-dihydrorifampicin  71397-49-4   Rifampin/*analogs & derivatives. Folia Biol 22(3):217;1976
DMB-rifampicin  13292-47-2   Rifampin/*analogs & derivatives. Biochem Biophys Res Comm 53(1):194;1973; Chem Biol Interact 18(1):59;1977; Invest Urol 14(5):366;1977; Nature New Biol 242(116):88;1973; Oncology 35:76;1978

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