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RNA Polymerase III

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Definition: A DNA-dependent RNA polymerase present in bacterial, plant, and animal cells. It functions in the nucleoplasmic structure where it transcribes DNA into RNA. It has specific requirements for cations and salt and has shown an intermediate sensitivity to alpha-amanitin in comparison to RNA polymerase I and II. EC 2.7.7.6.      Other names DNA-Dependent RNA Polymerase III; C, RNA Polymerase; RNA Polymerase C; Polymerase III, RNA; Polymerase C, RNA; III, RNA Polymerase; DNA Dependent RNA Polymerase III
 
SubstanceCAS Registry & nameCategoriesSourceDrugs*
POLR3G protein, human  EC 2.7.7.-   *RNA Polymerase III Protein Subunits. Stem Cells. 2011 Oct;29(10):1517-27.
POLR3G protein, mouse  EC 2.7.7.-   *RNA Polymerase III Protein Subunits. Stem Cells. 2011 Oct;29(10):1517-27.
RPC6 protein, mouse  0   *Carrier Proteins RNA Polymerase III Protein Subunits. Nucleic Acids Res 2008 Jun;36(11):3757-64
C25 protein, S cerevisiae  EC 2.7.7.-   *RNA Polymerase III *Saccharomyces cerevisiae Proteins Protein Subunits. Mol Cell Biol 1994 Sep;14(9):6164-70
C17 protein, S cerevisiae  EC 2.7.7.-   *RNA Polymerase III *Saccharomyces cerevisiae Proteins Protein Subunits. Mol Cell Biol 2000 Jan;20(2):488-95
RPC53 protein, S cerevisiae  EC 2.7.7.-   *RNA Polymerase III *Saccharomyces cerevisiae Proteins. Mol Cell Biol 1992 Oct;12(10):4314-26
RPC37 protein, S cerevisiae  EC 2.7.7.-   *RNA Polymerase III *Saccharomyces cerevisiae Proteins. EMBO J 2006 Jan 11;25(1):118-28
RPC11 protein, S cerevisiae  EC 2.7.7.-   *RNA Polymerase III *Saccharomyces cerevisiae Proteins. Genes Dev 1998 Dec 15;12(24):3857-71
POLR3E protein, human  EC 2.7.7.6   *RNA Polymerase III. Mol Cell Biol 2002 Nov;22(22):8044-55
POLR3B protein, human  EC 2.7.7.6   *RNA Polymerase III. Mol Cell Biol 2002 Nov;22(22):8044-55
BRF1 protein, human  0   *TATA-Binding Protein Associated Factors RNA Polymerase III Transcription Factor TFIIIB.
BN51 protein, human  EC 2.7.7.-   *Neoplasm Proteins *RNA Polymerase III *Cell Cycle Proteins. Cell Growth Differ 1994 Jul;5(7):783-8
ATRPAC14 protein, Arabidopsis  0   *RNA Polymerase III *Arabidopsis Proteins. Gene 1996 Jun 26;172(2):211-5
RPC34 protein, S cerevisiae  EC 2.7.7.6   *RNA Polymerase III *Saccharomyces cerevisiae Proteins. J Biol Chem 1992 Oct 25;267(30):21390-5

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Sources: NLM Medical Subject Headings, NIH UMLS, Drugs@FDA, FDA AERS original data copyright United States Government. No endorsement implied. Last modified 6/6/2012
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