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Sex Hormone-Binding Globulin

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Definition: A glycoprotein migrating as a beta-globulin. Its molecular weight, 52,000 or 95,000-115,000, indicates that it exists as a dimer. The protein binds testosterone, dihydrotestosterone, and estradiol in the plasma. Sex hormone-binding protein has the same amino acid sequence as ANDROGEN-BINDING PROTEIN. They differ by their sites of synthesis and post-translational oligosaccharide modifications.  does not refer to all sex hormones: refers to a specific protein in the blood binding only testosterone or estradiol; for other sex hormone-binding globulins consider ANDROGEN-BINDING PROTEIN & PROGESTERONE-BINDING GLOBULIN; DF: SHBG   
See Also Androgen-Binding Protein
Other names Testosterone-Estradiol Binding Globulin; Sex Steroid-Binding Protein; Testosterone Estradiol Binding Globulin; Steroid-Binding Protein, Sex; Sex Steroid Binding Protein; Sex Hormone Binding Globulin; Hormone-Binding Globulin, Sex; Globulin, Testosterone-Estradiol Binding; Globulin, Sex Hormone-Binding; Binding Globulin, Testosterone-Estradiol
 
SubstanceCAS Registry & nameCategoriesSourceDrugs*
sex hormone-binding globulin receptor  0   *Receptors, Cell Surface Sex Hormone-Binding Globulin. J Biol Chem 1990;265(11):6048

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Sources: NLM Medical Subject Headings, NIH UMLS, Drugs@FDA, FDA AERS original data copyright United States Government. No endorsement implied. Last modified 6/6/2012

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