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Sulbactam

More information in Books or onNLM PubMed
Definition: A beta-lactamase inhibitor with very weak antibacterial action. The compound prevents antibiotic destruction of beta-lactam antibiotics by inhibiting beta-lactamases, thus extending their spectrum activity. Combinations of sulbactam with beta-lactam antibiotics have been used successfully for the therapy of infections caused by organisms resistant to the antibiotic alone.     
Pharmacological Action Anti-Bacterial Agents; Enzyme Inhibitors 		Other names Sulfone, Penicillanic Acid; Sodium, Sulbactam; CP45899; CP 45899; Sulbactam Sodium; Pfizer Brand of Sulbactam Sodium; Penicillanic Acid Sulfone; Combactam; CP-45899; B+¬tamaze
 
SubstanceCAS Registry & nameCategoriesSourceDrugs*
6beta-(hydroxymethyl)penicillanic acid sulfone  0   Sulbactam/*analogs & derivatives. Biochem Pharmacol. 2012 Feb 15;83(4):462-71
Trifamox IBL  0   *Amoxicillin *Sulbactam Drug Combinations. Antibiot Khimioter. 2008;53(5-6):35-6, 38-41
6-diazopenicillanate sulfone  0   *Diazonium Compounds Sulbactam/*analogs & derivatives. J Med Chem 2003 Jun 19;46(13):2569-71
sulacillin  94935-63-4 4-Thia-1-azabicyclo03.2.0)heptane-2-carboxylic acid, 6-0(aminophenylacetyl)amino)-3,3-dimethyl-7-oxo-, 02S-02alpha,5alpha,6beta(S*)))-, mixt. with (2S-cis)-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo03.2.0)heptane-2-carboxylic acid 4,4-dioxide  *Ampicillin *Sulbactam Drug Combinations. Antibiot Khimioter 1994 Feb-Mar;39(2-3):45-8
sulperazone  92739-15-6   *Cefoperazone *Sulbactam Drug Combinations.
Pharma Action Anti-Infective Agents, Urinary 		Hinyokika Kiyo 1988;34(8):1503
sulbactam pivoxyl  69388-79-0   Sulbactam/*analogs & derivatives. J Antimicrob Chemother 1982;10(5):445
6-beta-(trifluoromethanesulfonyl)amido-penicillanic acid sulfone  83053-95-6 4-Thia-1-azabicyclo(3.2.0)heptane-2-carboxylic acid, 3,3-dimethyl-7-oxo-6-(((trifluoromethyl)sulfonyl)amino)-, 4,4-dioxide, (2S-(2alpha,5alpha,6beta))  Sulbactam/*analogs & derivatives beta-Lactamases/antagonists & inhibitors. FEBS Lett 1982;143(2):265
sultamicillin  76497-13-7 4-Thia-1-azabicyclo(3.2.0)heptane-2-carboxylic acid, 6-((aminophenylacetyl)amino)-3,3-dimethyl-7-oxo-, (((3,3-dimethyl-7-oxo-4-thia-1-azabicyclo(3.2.0)hept-2-yl)carbonyl)oxy)methyl ester, S,S-dioxide, (2S-(2alpha(2R*,5S*),5alpha,6beta(S*)))  Ampicillin Sulbactam.
Pharma Action Anti-Bacterial Agents 		J Antimicrob Chemother 1982;10(1):49UNASYN; AMPICILLIN AND SULBACTAM
6-chloropenicillanic acid sulfone  0   Sulbactam/*analogs & derivatives. Philos Trans R Soc Lond (Biol) 1980;289(1036):309

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Sources: NLM Medical Subject Headings, NIH UMLS, Drugs@FDA, FDA AERS original data copyright United States Government. No endorsement implied. Last modified 6/6/2012
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