Thyroxine (definition)

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Thyroxine

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Definition: The major hormone derived from the thyroid gland. Thyroxine is synthesized via the iodination of tyrosines (MONOIODOTYROSINE) and the coupling of iodotyrosines (DIIODOTYROSINE) in the THYROGLOBULIN. Thyroxine is released from thyroglobulin by proteolysis and secreted into the blood. Thyroxine is peripherally deiodinated to form TRIIODOTHYRONINE which exerts a broad spectrum of stimulatory effects on cell metabolism.

/blood: consider also HYPERTHYROXINEMIA
See Also Hyperthyroxinemia; Receptors, Thyroid Hormone

Other names T4 Thyroid Hormone; Levothyroxine; L-Thyroxine; Thyroid Hormone, T4; LevoT; Levo T; Leo, Tiroxina; LThyroxin beta; LThyroxin Henning; L Thyroxine Roche; L Thyroxine; L Thyroxin beta; L Thyroxin Henning; L Thyrox; Delalande, Levothyroxin; Deladande, Levothyroxin; Berlin Chemie Brand of Levothyroxine Sodium; betapharm Brand of Levothyroxine Sodium; Watson Brand of Levothyroxine Sodium; Vortex Brand of Levothyroxine Sodium

Drugs* : THYROLAR-0.25; LEVOXYL; LEVO-T; THYROLAR-1; THYROLAR-2; LEVOTHROID; UNITHROID; THYROLAR-3; EUTHROID-0.5; EUTHROID-1; THYROLAR-5; EUTHROID-2; EUTHROID-3; THYROLAR-0.5; LEVOLET; SYNTHROID; LEVOTHYROXINE SODIUM; NOVOTHYROX; TIROSINT

Substance	CAS Registry & name	Categories	Source
3,5,3',5'-tetraiodothyropropionic acid	0	Thyroxine/*analogs & derivatives 3-Hydroxysteroid Dehydrogenases.	Org Lett 2000 Aug 24;2(17):121-8
thyroxine glucuronide	21462-56-6	Glucuronates Thyroxine/analogs & derivatives.	Endocr Res 1987;13(3):215
thyroxine sulfate	77074-49-8	Thyroxine/*analogs & derivatives.	Endocrinology 1985;117(1):8
thyroxamine	3571-49-1	Thyroxine/*analogs & derivatives.	Endokrinologie 1982;79(2):315
3-maleimidobenzoylthyroxine methyl ester	69343-52-8 L-Tyrosine, N-(3-(2,5-dihydro-2,5-dioxo-1H-pyrrol-1-yl)benzoyl)-O-(4-hydroxy-3,5-diiodophenyl)-3,5-diiodo-, methyl ester	Thyroxine/*analogs & derivatives.	Biochem Biophys Res Commun 85(2):671;1978
thyroxine, triiodothyronine drug combination	8061-58-3 O-(4-hydroxy-3,5-diiodophenyl)-3,5-diiodo-L-tyrosine mixt. with O-(4-hydroxy-3-iodophenyl)-3,5-diiodo-L-tyrosine	Thyroxine Triiodothyronine Drug Combinations.	Med Lett Drug Ther 12(18):73;1970; Pol Tyg Lek 1979;34(47):1841; Pol Tyg Lek 31(52):2233;1976; Sem Hop 54(41-42):1291;1978
N-bromoacetylthyroxine	64379-24-4 L-Tyrosine, N-(bromoacetyl)-O-(4-hydroxy-3,5-diiodophenyl)-3,5-diiodo	Thyroxine/*analogs & derivatives.	J Biol Chem 252(17):6076;1977
tetraiodothyroacetic acid	67-30-1	Thyroxine/*analogs & derivatives.	Acta Endocrinol (Copenh) 1979;92(3):455; Clin Chim Acta 94(3):267;1979; J Clin Endocrinol Metab 1980;50(4):712; J Endocrinol 81(2):115P;1979; Lancet 1(7961):653;1976; Proc R Soc Med 68(2):69;1975
3,3',5,5'-tetraiodothyroformic acid	2055-97-2	Thyroxine/*analogs & derivatives.	Biochem J 143(1):47;1974
etiroxate	17365-01-4	Thyroxine/analogs & derivatives. Pharma Action* Hypolipidemic Agents	Acta Physiol Pol 29(2):117;1978; Arzneim Forsch 1979;29(3):499; Arzneim Forsch 27(1):422;1977; Dtsch Med Wochenschr 15(11):815;1975; Fortschr Med 1979;97(42):1942; Med Klin 1980;75(1):35; Med Klin 71(38):1555;1976; Med Welt 28(4):186;1977; Munch Med Wochenschr 120(21):739;1978; Verh Dtsch Ges Inn Med 82(2):874;1976; Verh Dtsch Ges Inn Med 83:392;1977; Wiad Lek 1979 32(14):987; Wiad Lek 1979;32(16):1135

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Sources: NLM Medical Subject Headings, NIH UMLS, Drugs@FDA, FDA AERS original data copyright United States Government. No endorsement implied. Last modified 6/6/2012
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