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Toyocamycin

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Definition: 4-Amino-5-cyano-7-(D-ribofuranosyl)-7H- pyrrolo(2,3-d)pyrimidine. Antibiotic antimetabolite isolated from Streptomyces toyocaensis cultures. It is an analog of adenosine, blocks RNA synthesis and ribosome function, and is used mainly as a tool in biochemistry.  an antineoplastic antibiotic & antimetabolite   
Pharmacological Action Antibiotics, Antineoplastic; Antimetabolites, Antineoplastic 		Other names Toyokamycin; Deazacyanoadenosine
 
SubstanceCAS Registry & nameCategoriesSourceDrugs*
MCS-C2  0   Toyocamycin/*analogs & derivatives. Cancer Lett 2005 Jun 8;223(2):239-47
5'-deoxytoyocamycin  65562-55-2   Toyocamycin/*analogs & derivatives. J Antibiot (Tokyo) 1991;44(7):729
2'-deoxytoyocamycin-5'-triphosphate  67460-16-6 7H-Pyrrolo(2,3-d)pyrimidine-5-carbonitrile, 4-amino-7-(2-deoxy-5-O-(hydroxy((hydroxy(phosphonooxy)phosphinyl)oxy)phosphinyl)-beta-D-erythro-pentofuranosyl)  Toyocamycin/*analogs & derivatives. Biochemistry 17(12):2350;1978
toyocamycin 3',5'-cyclic phosphate  52134-58-4 7H-Pyrrolo(2,3-d)pyrimidine-5-carbonitrile, 4-amino-7-(3,5-O-phosphinico-beta-D-ribofuranosyl)  Toyocamycin/*analogs & derivatives. Biochem Biophys Res Commun 55(3):843;1973
thiotoyocamycin  34635-46-6   Toyocamycin/*analogs & derivatives. J Med Chem 15(2):168;1972

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Sources: NLM Medical Subject Headings, NIH UMLS, Drugs@FDA, FDA AERS original data copyright United States Government. No endorsement implied. Last modified 6/6/2012
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