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Uroporphyrinogens

More information in Books or onNLM PubMed
Definition: Porphyrinogens which are intermediates in heme biosynthesis. They have four acetic acid and four propionic acid side chains attached to the pyrrole rings. Uroporphyrinogen I and III are formed from polypyrryl methane in the presence of uroporphyrinogen III cosynthetase and uroporphyrin I synthetase, respectively. They can yield uroporphyrins by autooxidation or coproporphyrinogens by decarboxylation.  porphyrins    Other names Uroporphyrinogen III
 
SubstanceCAS Registry & nameCategoriesSourceDrugs*
N(D)-methyl-1-formylbilane  0   *Uroporphyrinogens. Proteins 2008 May 1;71(2):855-73
19-methyl-1-hydroxymethylbilane  0   *Uroporphyrinogens Uroporphyrinogen III Synthetase/antagonists & inhibitors. Bioorg Med Chem 1994 Apr;2(4):267-77
19-bromo-1-hydroxymethylbilane  0   *Uroporphyrinogens Uroporphyrinogen III Synthetase/antagonists & inhibitors. Bioorg Med Chem 1994 Apr;2(4):267-77
hydroxymethylbilane  71861-60-4 21H-biline-2,7,12,17-tetrapropanoic acid, 3,8,13,18-tetrakis(carboxymethyl)-5,10,15,22,23,24-hexahydro-19-(hydroxymethyl)  *Uroporphyrinogens Hydroxymethylbilane Synthase. Nature 1980;285(5759):19

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Sources: NLM Medical Subject Headings, NIH UMLS, Drugs@FDA, FDA AERS original data copyright United States Government. No endorsement implied. Last modified 6/6/2012
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