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Veratrum Alkaloids

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Definition: Alkaloids with powerful hypotensive effects isolated from American or European Hellebore (Veratrum viride Ait. Liliaceae and Veratrum album L. Liliaceae). They increase cholinergic and decrease adrenergic tone with appropriate side effects and at higher doses depress respiration and produce cardiac arrhythmias; only the ester alkaloids have been used as hypotensive agents in specific instances. They have been generally replaced by drugs with fewer adverse effects.  antihypertensives   
Pharmacological Action Antihypertensive Agents
Examples Cevanes 		Other names Alkaloids, VeratrumDrugs* : VERTAVIS; VERILOID
 
SubstanceCAS Registry & nameCategoriesSourceDrugs*
3-keto-N-aminoethylaminoethylcaproyldihydrocinnamoyl cyclopamine  0   *Cinnamates *Veratrum Alkaloids. Neurobiol Dis. 2009 May;34(2):259-66
IPI-926  0   *Veratrum Alkaloids. Science 2009 Jun 12;324(5933):1457-61
puqienin F  0   *Veratrum Alkaloids. Chem Pharm Bull (Tokyo). 2006 May;54(5):722-4
germerine  508-67-8   *Veratrum Alkaloids. J Asian Nat Prod Res 2000;2(2):133-44
germidine  465-77-0   *Veratrum Alkaloids. J Asian Nat Prod Res 2000;2(2):13-44
vertaline B  118985-28-7 16,28-Secosolanid-5-ene-3,16,20-triol, (3beta,16beta)  *Veratrum Alkaloids Drugs, Chinese Herbal. Yao Hsueh Hsueh Pao 1988;23(8):584
ningpeisine  117695-02-0 Veratraman-6(5H)-one, 12,13-dihydro-3-hydroxy-28-methyl-, (3beta,5alpha,12alpha,13beta)  *Veratrum Alkaloids Drugs, Chinese Herbal. Yao Hsueh Hsueh Pao 1988;23(6):415
verazine  14320-81-1   *Veratrum Alkaloids. Chung Yao Tung Pao 1987;12(1):34
beta-chaconine  472-51-5   Solanine/*analogs & derivatives Veratrum Alkaloids. Yao Hsueh Hsueh Pao 1984;19(6):431
stenophylline C  91450-14-5   *Veratrum Alkaloids. Yao Hsueh Hsueh Pao 1984;19(6):431
stenophylline D  91450-15-6   *Veratrum Alkaloids. Yao Hsueh Hsueh Pao 1984;19(6):431
cycloposine  23185-94-6 17,23 beta-epoxyveratraman-3 beta-yl-beta-D- glucopyranoside  *Veratrum Alkaloids. Lipids 13(10):708;1978
jervine  469-59-0 17,23 beta-epoxy-3 beta-hydroxyveratraman-11-one  *Veratrum Alkaloids. J Chromatogr 119:223;1976; Lipids 13(10):708;1978; Proc Soc Exp Biol Med 149(1):302;1975
veratramine  60-70-8 (3 beta,23 beta)-14,15,16,17-tetradehydroveratraman-3,23-diol  *Veratrum Alkaloids. J Chromatogr 119:223;1976; J Pharmacol Exp Ther 210(1):116;1979; Lipids 13(10):708;1978
SC 19886  22785-18-8 17-beta-hydroxy-12-alpha-etiojerv-4-en-3-one  *Veratrum Alkaloids. J Steroid Biochem 3(2):201;1972
muldamine  36069-45-1   *Veratrum Alkaloids. Lipids 13(10):708;1978; Steroids 18(6):741;1971
cyclopamine  4449-51-8   *Veratrum Alkaloids. Lipids 13(10):708;1978; Proc Soc Exp Biol Med 149(1):302;1975; Science 176(031):133;1972

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Sources: NLM Medical Subject Headings, NIH UMLS, Drugs@FDA, FDA AERS original data copyright United States Government. No endorsement implied. Last modified 6/6/2012
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