Definition: An alpha-globulin found in the plasma of man and other vertebrates. It is apparently synthesized in the liver and carries vitamin D and its metabolites through the circulation and mediates the response of tissue. It is also known as group-specific component (Gc). Gc subtypes are used to determine specific phenotypes and gene frequencies. These data are employed in the classification of population groups, paternity investigations, and in forensic medicine.
Other names Vitamin D-Binding Globulin; Group-Specific Component Globulin; Vitamin D Binding Protein; Vitamin D Binding Globulin; Group Specific Component Globulin; Globulin, Vitamin D-Binding; Globulin, Group-Specific Component; Globulin, Gc; Component Globulin, Group-Specific; Calciferol Binding Protein; 25 Hydroxyvitamin D Binding Protein; 25 Hydroxycholecalciferol Binding Protein; 25 HCC Binding Protein; Transcalciferin; Gc Globulin; Calciferol-Binding Protein; 25-Hydroxyvitamin D-Binding Protein; 25-Hydroxycholecalciferol-Binding Protein; 25-HCC-Binding Protein