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2-Isopropylmalate Synthase

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Definition: An enzyme that catalyzes the first step in the biosynthetic pathway to LEUCINE, forming isopropyl malate from acetyl-CoA and alpha-ketoisovaleric acid. This enzyme was formerly listed as EC 4.1.3.12.      Other names alpha Isopropylmalate Synthase; Synthase, alpha-Isopropylmalate; Synthase, 2-Isopropylmalate; 2 Isopropylmalate Synthase; alpha-Isopropylmalate Synthase
 
SubstanceCAS Registry & nameCategoriesSourceDrugs*
MAM3 protein, Arabidopsis  EC 2.3.3.13   *2-Isopropylmalate Synthase *Arabidopsis Proteins. Plant Physiol 2007 May;144(1):60-71
LEU4 protein, S cerevisiae  EC 2.3.3.13   *2-Isopropylmalate Synthase *Saccharomyces cerevisiae Proteins. Mol Microbiol 1993 Jan;7(2):215-28

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Sources: NLM Medical Subject Headings, NIH UMLS, Drugs@FDA, FDA AERS original data copyright United States Government. No endorsement implied. Last modified 6/6/2012
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