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2',3'-Cyclic-Nucleotide Phosphodiesterases

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Definition: Nucleoside-2',3'-cyclic phosphate nucleotidohydrolase. Enzymes that catalyze the hydrolysis of the 2'- or 3'- phosphate bonds of 2',3'-cyclic nucleotides. Also hydrolyzes nucleoside monophosphates. Includes EC 3.1.4.16 and EC 3.1.4.37. EC 3.1.4.-.  DF: 2 3 CYCL NPD    Other names Phosphodiesterases, 2,3-Cyclic Nucleotide; Phosphodiesterases, 2',3'-Cyclic-Nucleotide; Phosphodiesterases, 2',3'-Cyclic Nucleotide; Phosphodiesterase, 2,3-Cyclic Nucleotide; Phosphodiesterase, 2',3'-Cyclic Nucleotide; Nucleotide Phosphodiesterases, 2,3-Cyclic; Nucleotide Phosphodiesterases, 2',3'-Cyclic; Nucleotide Phosphodiesterase, 2,3-Cyclic; Nucleotide Phosphodiesterase, 2',3'-Cyclic; 2,3 Cyclic Nucleotide Phosphodiesterases; 2,3 Cyclic Nucleotide Phosphodiesterase; 2',3' Cyclic Nucleotide Phosphodiesterases; 2',3' Cyclic Nucleotide Phosphodiesterase; CNPase; 2,3-Cyclic Nucleotide Phosphodiesterases; 2,3-Cyclic Nucleotide Phosphodiesterase; 2',3'-Cyclic Nucleotide Phosphodiesterases; 2',3'-Cyclic Nucleotide Phosphodiesterase
 
SubstanceCAS Registry & nameCategoriesSourceDrugs*
gRICH70 protein, Carassius auratus  EC 3.1.4.-   *Nerve Tissue Proteins *2',3'-Cyclic-Nucleotide Phosphodiesterases *Fish Proteins Nerve Regeneration. J Biol Chem 1997 Apr 25;272(17):11479-86
gRICH68 protein, Carassius auratus  EC 3.1.4.-   *Nerve Tissue Proteins *2',3'-Cyclic-Nucleotide Phosphodiesterases *Fish Proteins Nerve Regeneration. J Biol Chem 1997 Apr 25;272(17):11479-86
griseolic acid 8'-pivaloyloxymethyl ester  124254-35-9   Adenosine/*analogs & derivatives 2',3'-Cyclic-Nucleotide Phosphodiesterases/antagonists & inhibitors. Jpn J Opthamol 1991;35(1):23
KS 502  120634-85-7   *Hydroxybenzoic Acids 2',3'-Cyclic-Nucleotide Phosphodiesterases/antagonists & inhibitors. J Antibiot (Tokyo) 1989;42(7):1049
KS 501  120634-86-8 Benzoic acid, 2-(beta-D-galactofuranosyloxy)-6-heptyl-4-hydroxy-, 3-heptyl-5-hydroxyphenyl ester  *Hydroxybenzoic Acids 2',3'-Cyclic-Nucleotide Phosphodiesterases/antagonists & inhibitors. J Antibiot (Tokyo) 1989;42(7):1049
siguazodan  115344-47-3   *Guanidines *Pyridazines 2',3'-Cyclic-Nucleotide Phosphodiesterases/antagonists & inhibitors.
Pharma Action Phosphodiesterase Inhibitors ; Vasodilator Agents
Br J Pharmacol 1988;93(4):893
neucrassin, Neurospora  0   *Fungal Proteins Neurospora crassa 2',3'-Cyclic-Nucleotide Phosphodiesterases. Biochem Biophys Res Commun 1985;130(3):1015
7-chloro-5-propyl-1,2,4-triazolo(4,3-a)quinoxaline-1,4(2H,5H)-dione  80708-33-4 (1,2,4)Triazolo(4,3-a)quinoxaline-1,4(2H,5H)-dione, 7-chloro-5-propyl  *Triazoles 2',3'-Cyclic-Nucleotide Phosphodiesterases/antagonists & inhibitors 3',5'-Cyclic-AMP Phosphodiesterases/antagonists & inhibitors. Int Arch Allergy Appl Immunol 1984;73(1):56
2',3'-cyclic nucleotide 2'-phosphodiesterase  EC 3.1.4.16   *2',3'-Cyclic-Nucleotide Phosphodiesterases.
cephalochromin  25908-26-3 2,2',3,3'-tetrahydro-5,5',6,6',8,8'-hexahydroxy-2, 2'-dimethyl-9,9'-bi-4H-naphtho(2,3-b)pyran-4,4'-dione  *Cephalosporins 2',3'-Cyclic-Nucleotide Phosphodiesterases/antagonists & inhibitors. J Nat Prod 38(5):448;1975

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Sources: NLM Medical Subject Headings, NIH UMLS, Drugs@FDA, FDA AERS original data copyright United States Government. No endorsement implied. Last modified 6/6/2012

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