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2',5'-Oligoadenylate Synthetase

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Definition: An enzyme that catalyzes the conversion of ATP into a series of (2'-5') linked oligoadenylates and pyrophosphate in the presence of double-stranded RNA. These oligonucleotides activate an endoribonuclease (RNase L) which cleaves single-stranded RNA. Interferons can act as inducers of these reactions. EC 2.7.7.-.      Other names Synthetase, 2,5 Oligoadenylate; Synthetase, 2',5'-Oligoadenylate; Polymerase, 2,5 Oligoadenylate; Polymerase, 2',5'-Oligoadenylate; Oligoadenylate Synthetase, 2,5; Oligoadenylate Polymerase, 2,5; 2-5A Synthetase; 2',5'-Oligoadenylate Polymerase; 2',5' Oligoadenylate Synthetase; 2',5' Oligoadenylate Polymerase; 2 5A Synthetase; ATP-(2'-5')oligo(A)adenylyltransferase; 2,5 Oligoadenylate Synthetase; 2,5 Oligoadenylate Polymerase; 2',5'-Oligo(A) Synthetase; 2',5'-Oligo(A) Polymerase; (2'-5')An Polymerase
 
SubstanceCAS Registry & nameCategoriesSourceDrugs*
Oas1b protein, mouse  EC 2.7.7.-   *2',5'-Oligoadenylate Synthetase. J Interferon Cytokine Res 2002 Sep;22(9):981-93
Oas1d protein, mouse  EC 2.7.7.-   *2',5'-Oligoadenylate Synthetase. Mol Cell Biol 2005 Jun;25(11):4615-24
OAS1 protein, human  EC 2.7.7.-   *2',5'-Oligoadenylate Synthetase. J Biochem (Tokyo) 1986 May;99(5):1455-64
Oasl2 protein, mouse  EC 2.7.7.-   *2',5'-Oligoadenylate Synthetase. Nucleic Acids Res 2003 Jun 15;31(12):3166-73
Oasl1 protein, mouse  EC 2.7.7.-   2',5'-Oligoadenylate Synthetase. Cell Mol Life Sci 2002 Jul;59(7):1212-22
Oas1c protein, mouse  EC 2.7.7.-   *2',5'-Oligoadenylate Synthetase. Gene 2001 Jun 27;271(2):261-71
p30 oligoadenylate synthetase  EC 2.7.7.-   *2',5'-Oligoadenylate Synthetase. Eur J Biochem 1998 Oct 15;257(2):319-30
p56 oligoadenylate synthetase  EC 2.7.7.-   *2',5'-Oligoadenylate Synthetase. Eur J Biochem 1998 Oct 15;257(2):319-30
OASL protein, human  EC 2.7.7.-   *2',5'-Oligoadenylate Synthetase. Genomics 1999 Mar 15;56(3):362-3; Nucleic Acids Res 1998 Sep 15;26(18):4121-7

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Sources: NLM Medical Subject Headings, NIH UMLS, Drugs@FDA, FDA AERS original data copyright United States Government. No endorsement implied. Last modified 6/6/2012
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