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5,6-Dihydroxytryptamine

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Definition: Tryptamine substituted with two hydroxyl groups in positions 5 and 6. It is a neurotoxic serotonin analog that destroys serotonergic neurons preferentially and is used in neuropharmacologic research.     
Pharmacological Action Serotonin Agents 		Other names 5,6 Dihydroxytryptamine; 3-(2-Aminoethyl)indole-5,6-diol
 
SubstanceCAS Registry & nameCategoriesSourceDrugs*
5,7-dihydroxytryptamine creatinine  36928-25-3   Creatinine/*analogs & derivatives 5,6-Dihydroxytryptamine/*analogs & derivatives. Brain Res 1992 Sep 18;591(1):116-21
4,7-difluoro-5,6-dihydroxytryptamine creatinine  133983-26-3   5,6-Dihydroxytryptamine/*analogs & derivatives. J Med Chem 1990;33(8):2204
5,6-dihydroxy-7-fluorotryptamine creatinine  127685-99-8   5,6-Dihydroxytryptamine/*analogs & derivatives. J Med Chem 1990;33(8):2204
5,6-dihydroxy-4-fluorotryptamine creatinine  127709-37-9   5,6-Dihydroxytryptamine/*analogs & derivatives. J Med Chem 1990;33(8):2204
7-methyl-5,6-dihydroxytryptamine  97073-69-3   5,6-Dihydroxytryptamine/*analogs & derivatives. J Med Chem 1985;28(9):1273
4-methyl-5,6-dihydroxytryptamine  97073-66-0   5,6-Dihydroxytryptamine/*analogs & derivatives. J Med Chem 1985;28(9):1273
4,7-dimethyl-5,6-dihydroxytryptamine  97073-72-8   5,6-Dihydroxytryptamine/*analogs & derivatives. J Med Chem 1985;28(9):1273

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Sources: NLM Medical Subject Headings, NIH UMLS, Drugs@FDA, FDA AERS original data copyright United States Government. No endorsement implied. Last modified 6/6/2012
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