encyclopedia of medical concepts
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Second Messenger Systems

More information in Books or onNLM PubMed
Definition: Systems in which an intracellular signal is generated in response to an intercellular primary messenger such as a hormone or neurotransmitter. They are intermediate signals in cellular processes such as metabolism, secretion, contraction, phototransduction, and cell growth. Examples of second messenger systems are the adenyl cyclase-cyclic AMP system, the phosphatidylinositol diphosphate-inositol triphosphate system, and the cyclic GMP system.  a metab concept; IM; coord with substance acting as the second messenger (IM) with /physiol or /antag as applicable; DF: SECOND MESSENGERS   
Examples Calcium Signaling 		Other names Intracellular Second Messengers; System, Second Messenger; Second Messengers, Intracellular; Systems, Second Messenger; Second Messenger, Intracellular; Second Messenger System; Second Messenger; Messengers, Second; Messengers, Intracellular Second; Messenger, Second; Intracellular Second Messenger; Second Messengers
 
SubstanceCAS Registry & nameCategoriesSource
PsiP protein, Zea mays  EC 4.6.1.1   *Adenylate Cyclase *Plant Proteins Second Messenger Systems. Proc Natl Acad Sci U S A 2001 Aug 28;98(18):10481-6
Spo0F protein, Bacillus subtilis  0   *Bacterial Proteins Phosphotransferases Spores, Bacterial Second Messenger Systems. Mol Microbiol 1993 Mar;7(6):967-74
diadenosine tetraphosphate  5542-28-9 adenosine 5'-(pentahydrogen tetraphosphate), 5'-5'-ester with adenosine  *Dinucleoside Phosphates Second Messenger Systems.
Pharma Action Platelet Aggregation Inhibitors 		Biochim Biophys Acta 276(2):563;1972; Cold Spring Harbor SympQuant Biol 1979;43(1):649; FEBS Lett 1979;107(1):121; Proc Natl Acad Sci USA 1979;76(12):6081; Specific Eukaryotic Genes W3 AL36 13th:383;1978

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Sources: NLM Medical Subject Headings, NIH UMLS, Drugs@FDA, FDA AERS original data copyright United States Government. No endorsement implied. Last modified 6/6/2012
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