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Pentostatin

More information in Books or onNLM PubMed
Definition: A potent inhibitor of ADENOSINE DEAMINASE. The drug induces APOPTOSIS of LYMPHOCYTES, and is used in the treatment of many lymphoproliferative malignancies, particularly HAIRY CELL LEUKEMIA. It is also synergistic with some other antineoplastic agents and has immunosuppressive activity.     
Pharmacological Action Adenosine Deaminase Inhibitors; Antineoplastic Agents 		Other names NSC-218321; Lederle Brand of Pentostatin; Deoxycoformycin; Co-Vidarabine; CI-825; 2'-Deoxycoformycin; NSC218321; NSC 218321; Co Vidarabine; CI825; CI 825; 2' Deoxycoformycin; Wyeth Brand of Pentostatin; Warner-Lambert Brand of Pentostatin; Supergen Brand of Pentostatin; Prasfarma Brand of Pentostatin; NipentDrugs* : NIPENT; PENTOSTATIN
 
SubstanceCAS Registry & nameCategoriesSourceDrugs*
carbapentostain  0   Pentostatin/*analogs & derivatives. J Org Chem 2003 Jan 10;68(1):109-14
adechlorin  96328-17-5 Imidazo(4,5-d)(1,3)diazepin-8-ol, 3-(2-chloro-2-deoxy-beta-D-ribofuranosyl)-3,4,7,8-tetrahydro-, (R)  Pentostatin/*analogs & derivatives Adenosine Deaminase/antagonists & inhibitors. J Antibiot (Tokyo) 1985;38(8):1008
8-ketodeoxycoformycin  69196-03-8   Pentostatin/*analogs & derivatives. Biochemistry 1985;24(3):641
2'-deoxycoformycin 5'-phosphate  72490-67-6 Imidazo(4,5-d)(1,3)diazepin-8-ol, 3-(2-deoxy-5-O-phosphono-beta-D-erythro-pentofuranosyl)-3,4,7,8-tetrahydro-, (R)  Pentostatin/*analogs & derivatives. Biochem Biophys Res Commun 91(1):278;1979

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Sources: NLM Medical Subject Headings, NIH UMLS, Drugs@FDA, FDA AERS original data copyright United States Government. No endorsement implied. Last modified 6/6/2012
Warning: the drugs or drug combinations referred to here may be similar or related, but are not be the same ones and may not have the same pharmacological action as other substances described on the same page or in the same row. Please refer to product monograph or to your doctor
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