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7-Alkoxycoumarin O-Dealkylase

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Definition: A drug-metabolizing enzyme found in the hepatic, placental and intestinal microsomes that metabolizes 7-alkoxycoumarin to 7-hydroxycoumarin. The enzyme is cytochrome P-450- dependent.      Other names 7-Ethoxycoumarin O-Deethylase; 7-Ethoxycoumarin O-Dealkylase; P-450-Dependent O-Dealkylase, Cytochrome; O-Depropylase, 7-Propoxycoumarin; O-Deethylase, 7-Ethoxycoumarin; Monooxygenase, 7-Ethoxycoumarin; Hydroxylase, 7-Ethoxycoumarin; Ethoxycoumarin O Deethylase; Deethylase, Ethoxycoumarin; Dealkylase, 7-Ethoxycoumarin; Cytochrome P 450 Dependent O Dealkylase; 7 Propoxycoumarin O Depropylase; 7 Ethoxycoumarin O Deethylase; 7 Ethoxycoumarin O Dealkylase; 7 Ethoxycoumarin O De Ethylase; 7 Ethoxycoumarin Monooxygenase; 7 Ethoxycoumarin Hydroxylase; 7 Ethoxycoumarin Dealkylase; 7 Alkoxycoumarin O Dealkylase; Ethoxycoumarin O-Deethylase
 
SubstanceCAS Registry & nameCategoriesSourceDrugs*
3-cyano-7-ethoxycoumarin-o-deethylase, Littorina littorea  EC 1.14.13.-   *7-Alkoxycoumarin O-Dealkylase. Mar Environ Res 2006 Jun;61(5):457-70
cytochrome P-450 CYP76B1 (Helianthus tuberosus)  EC 1.14.13.-   *7-Alkoxycoumarin O-Dealkylase. Plant J 1998 Apr;14(1):111-20
9-ethynylphenanthrene  0   *Phenanthrenes 7-Alkoxycoumarin O-Dealkylase/antagonists & inhibitors. Arch Biochem Biophys 1995 Nov 10;323(2):295-302

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Sources: NLM Medical Subject Headings, NIH UMLS, Drugs@FDA, FDA AERS original data copyright United States Government. No endorsement implied. Last modified 6/6/2012

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