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Gene Products, nef

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Definition: Products of the retroviral NEF GENE. They play a role as accessory proteins that influence the rate of viral infectivity and the destruction of the host immune system. nef gene products were originally found as factors that trans-suppress viral replication and function as negative regulators of transcription. nef stands for negative factor.     
Examples nef Gene Products, Human Immunodeficiency Virus 		Other names nef Gene Product; 3' orf Protein; Gene Product, nef; 3'-orf Protein; nef Protein; nef Gene Products
 
SubstanceCAS Registry & nameCategoriesSourceDrugs*
GST-Nef protein, recombinant  0   *Glutathione Transferase *Recombinant Fusion Proteins *Gene Products, nef. AIDS Res Hum Retroviruses 1994 Aug;10(8):1011-9

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Sources: NLM Medical Subject Headings, NIH UMLS, Drugs@FDA, FDA AERS original data copyright United States Government. No endorsement implied. Last modified 6/6/2012
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