encyclopedia of medical concepts
ψ 
ψ 
ψ 
ψ 

Factor XIIa

More information in Books or onNLM PubMed
Definition: Activated form of factor XII. In the initial event in the intrinsic pathway of blood coagulation, kallikrein (with cofactor HIGH MOLECULAR WEIGHT KININOGEN) cleaves factor XII to XIIa. Factor XIIa is then further cleaved by kallikrein, plasmin, and trypsin to yield smaller factor XII fragments (Hageman-Factor fragments). These fragments increase the activity of prekallikrein to kallikrein but decrease the procoagulant activity of factor XII.  /defic   
See Also Coagulants 		Other names Factor XII, Activated; Coagulation Factor XIIa; XIIa, Coagulation Factor; Hageman Factor Fragments; Fragments, Hageman-Factor; Factor XIIa, Coagulation; Activator, Prekallikrein; Prekallikrein Activator; Hageman-Factor Fragments; Blood Coagulation Factor XII, Activated; Activated Factor XII
 
SubstanceCAS Registry & nameCategoriesSourceDrugs*
CMTI protein, Cucurbita maxima  0   *Plant Proteins Factor XIIa/antagonists & inhibitors. Protein Expr Purif 1993 Jun;4(3):215-22

To share this definition, click "text" (Facebook, Twitter) or "link" (blog, mail) then paste text link
Ads by Google

Sources: NLM Medical Subject Headings, NIH UMLS, Drugs@FDA, FDA AERS original data copyright United States Government. No endorsement implied. Last modified 6/6/2012
Warning: the drugs or drug combinations referred to here may be similar or related, but are not be the same ones and may not have the same pharmacological action as other substances described on the same page or in the same row. Please refer to product monograph or to your doctor
This website is accredited by Health On the Net Foundation. Click to verify. We comply with the HONcode standard for trustworthy health information: verify here.
About Reference.MD Privacy