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Didanosine

More information in Books or onNLM PubMed
Definition: A dideoxynucleoside compound in which the 3'-hydroxy group on the sugar moiety has been replaced by a hydrogen. This modification prevents the formation of phosphodiester linkages which are needed for the completion of nucleic acid chains. Didanosine is a potent inhibitor of HIV replication, acting as a chain-terminator of viral DNA by binding to reverse transcriptase; ddI is then metabolized to dideoxyadenosine triphosphate, its putative active metabolite.     
Pharmacological Action Anti-HIV Agents; Antimetabolites; Reverse Transcriptase Inhibitors 		Other names ddI (Antiviral); Dideoxyinosine; 2',3'-Dideoxyinosine; NSC612049; NSC 612049; Bristol Myers Squibb Brand of Didanosine; Bristol Myers Brand of Didanosine; 2',3' Dideoxyinosine; NSC-612049; Bristol-Myers Squibb Brand of Didanosine; Bristol-Myers Brand of Didanosine; VidexDrugs* : VIDEX; DIDANOSINE; VIDEX EC
 
SubstanceCAS Registry & nameCategoriesSourceDrugs*
5'-O-valyldidanosine  0   Valine/*analogs & derivatives Didanosine/*analogs & derivatives. Mol Pharm 2011 Apr 4;8(2):319-29
VS411  0   *Didanosine Drug Combinations Urea/*analogs & derivatives. Expert Opin Investig Drugs. 2011 Apr;20(4):559-65
2-aza-3-deaza-2',3'-dideoxyinosine  0   Didanosine/*analogs & derivatives. Bioorg Med Chem 1999 Nov;7(11):2373-9
2',3'-dideoxy-2,8-diaza-3-deazainosine  0   Didanosine/*analogs & derivatives. Bioorg Med Chem 1999 Nov;7(11):2373-9
dipalmitoylphosphatidyl-2',3'-dideoxyinosine  0   Didanosine/*analogs & derivatives. Antiviral Res 1997 May;34(3):91-9
scriptene  0   *Dideoxynucleotides Zidovudine/*analogs & derivatives Didanosine/*analogs & derivatives. J Clin Pharmacol 1997 Mar;37(3):201-13
2'-fluoro-2',3'-dideoxyinosine  134892-26-5   Didanosine/*analogs & derivatives. Mol Pharmacol 1993 Sep;44(3):519-23
9-(2,3-dideoxy-2-fluoro-betaD-threo-pentofuranosyl)hypoxanthine  117525-25-4   Didanosine/*analogs & derivatives. Nucleic Acids Res 1992 Feb 11;20(3):459-65

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Sources: NLM Medical Subject Headings, NIH UMLS, Drugs@FDA, FDA AERS original data copyright United States Government. No endorsement implied. Last modified 6/6/2012
Warning: the drugs or drug combinations referred to here may be similar or related, but are not be the same ones and may not have the same pharmacological action as other substances described on the same page or in the same row. Please refer to product monograph or to your doctor
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