encyclopedia of medical concepts
ψ 
ψ 
ψ 
ψ 
ψ 
ψ 
ψ 
ψ 
ψ 

Lymphocyte Function-Associated Antigen-1

More information in Books or onNLM PubMed
Definition: An integrin heterodimer widely expressed on cells of hematopoietic origin. CD11A ANTIGEN comprises the alpha chain and the CD18 antigen (ANTIGENS, CD18) the beta chain. Lymphocyte function-associated antigen-1 is a major receptor of T-CELLS; B-CELLS; and GRANULOCYTES. It mediates the leukocyte adhesion reactions underlying cytolytic conjugate formation, helper T-cell interactions, and antibody-dependent killing by NATURAL KILLER CELLS and granulocytes. Intracellular adhesion molecule-1 has been defined as a ligand for lymphocyte function-associated antigen-1.  DF: LFA1 or LFA 1    Other names alphaLbeta2, Integrin; Antigen-1, Lymphocyte Function-Associated; Integrin alphaLbeta2; Leukocyte Function Associated Antigen-1; LFA-1
 
SubstanceCAS Registry & nameCategoriesSourceDrugs*
2-(2,6-dichloro-4-((3-furan-2-ylacryloylamino)methyl)benzoylamino)-3-((thiazolidine-4-carbonyl)amino)propionic acid  0   *Acrylamides beta-Alanine/*analogs & derivatives Lymphocyte Function-Associated Antigen-1. Xenobiotics 2008 Mar;38(3):340-52
5-(9-(4-cyanophenyl)-3-(3,5-dichlorophenyl)-1-methyl-2,4-dioxo-1,3,7-triazaspiro(4,4)non-7-ylmethyl)-3-thiophenecarboxylic acid  0   *Spiro Compounds *Thiophenes Lymphocyte Function-Associated Antigen-1. J Med Chem 2006 Nov 30;49(24):6946-9
anti-LFA-1 monoclonal antibody  0   *Antibodies, Monoclonal Graft Rejection Immunosuppression Lymphocyte Function-Associated Antigen-1. Transplant Proc 1998 Aug;30(5):2163

To share this definition, click "text" (Facebook, Twitter) or "link" (blog, mail) then paste text link
Ads by Google

Sources: NLM Medical Subject Headings, NIH UMLS, Drugs@FDA, FDA AERS original data copyright United States Government. No endorsement implied. Last modified 6/6/2012
Warning: the drugs or drug combinations referred to here may be similar or related, but are not be the same ones and may not have the same pharmacological action as other substances described on the same page or in the same row. Please refer to product monograph or to your doctor
This website is accredited by Health On the Net Foundation. Click to verify. We comply with the HONcode standard for trustworthy health information: verify here.
About Reference.MD Privacy