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Motor Neuron Disease

More information in Books or onNLM PubMed
Definition: Diseases characterized by a selective degeneration of the motor neurons of the spinal cord, brainstem, or motor cortex. Clinical subtypes are distinguished by the major site of degeneration. In AMYOTROPHIC LATERAL SCLEROSIS there is involvement of upper, lower, and brainstem motor neurons. In progressive muscular atrophy and related syndromes (see MUSCULAR ATROPHY, SPINAL) the motor neurons in the spinal cord are primarily affected. With progressive bulbar palsy (BULBAR PALSY, PROGRESSIVE), the initial degeneration occurs in the brainstem. In primary lateral sclerosis, the cortical neurons are affected in isolation. (Adams et al., Principles of Neurology, 6th ed, p1089)  GEN or unspecified; prefer specifics   
Examples Amyotrophic Lateral Sclerosis; Bulbar Palsy, Progressive; Muscular Atrophy, Spinal 		Other names Motor Neuron Disease, Upper; Motor Neuron Disease, Lower; Lateral Sclerosis; Familial Motor Neuron Disease; Anterior Horn Cell Disease; Sclerosis, Primary Lateral; Sclerosis, Lateral; Scleroses, Primary Lateral; Scleroses, Lateral; Primary Lateral Scleroses; Neuron Diseases, Motor; Neuron Disease, Motor; Motor System Diseases; Motor Neuron Diseases; Lateral Sclerosis, Primary; Lateral Scleroses, Primary; Lateral Scleroses; Upper Motor Neuron Disease; Secondary Motor Neuron Disease; Primary Lateral Sclerosis
 
SubstanceCAS Registry & nameCategoriesSource
Primary lateral sclerosis juvenile  0   *Motor Neuron Disease.

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Sources: NLM Medical Subject Headings, NIH UMLS, Drugs@FDA, FDA AERS original data copyright United States Government. No endorsement implied. Last modified 6/6/2012
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