Definition: A 4-hydroxylated metabolite of AFLATOXIN B1, one of the MYCOTOXINS from ASPERGILLUS tainted food. It is associated with LIVER damage and cancer resulting from its P450 activation to the epoxide which alkylates DNA. Toxicity depends on the balance of liver enzymes that activate it (CYTOCHROME P-450) and others that detoxify it (GLUTATHIONE S TRANSFERASE) (Pharmac Ther 50.443 1991). Primates & rat are sensitive while mouse and hamster are tolerant (Canc Res 29.236 1969).
/antag permitted but consider also ANTITOXINS; DF: AFM1
Pharmacological ActionPoisons
Other names 4 Hydroxyaflatoxin B1; Aflatoxin M1, cis(+-)-Isomer; Aflatoxin M; 4-Hydroxyaflatoxin B1
